Jessica L. Keffer, Ph.D.

Affiliations: 
2012 Biochemistry & Molecular Georgetown University, Washington, DC 
Area:
Biochemistry, Microbiology Biology, Pharmaceutical Chemistry
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Carole A. Bewley grad student 2012 Georgetown
 (The structures, biological activity, and mechanistic studies of novel marine-derived antibacterial compounds.)
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Publications

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Keffer JL, Hahn MW, Maresca JA. (2015) Characterization of an Unconventional Rhodopsin from the Freshwater Actinobacterium Rhodoluna lacicola. Journal of Bacteriology. 197: 2704-12
Keffer JL, Sabanayagam CR, Lee ME, et al. (2015) Using total internal reflection fluorescence microscopy to visualize rhodopsin-containing cells. Applied and Environmental Microbiology. 81: 3442-50
Keffer JL, Huecas S, Hammill JT, et al. (2013) Chrysophaentins are competitive inhibitors of FtsZ and inhibit Z-ring formation in live bacteria. Bioorganic & Medicinal Chemistry. 21: 5673-8
Keffer JL, Hammill JT, Lloyd JR, et al. (2012) Geographic variability and anti-staphylococcal activity of the chrysophaentins and their synthetic fragments. Marine Drugs. 10: 1103-25
Cheruku P, Keffer JL, Dogo-Isonagie C, et al. (2010) Motualevic acids and analogs: synthesis and antimicrobial structure-activity relationships. Bioorganic & Medicinal Chemistry Letters. 20: 4108-11
Plaza A, Keffer JL, Bifulco G, et al. (2010) Chrysophaentins A-H, antibacterial bisdiarylbutene macrocycles that inhibit the bacterial cell division protein FtsZ. Journal of the American Chemical Society. 132: 9069-77
Plaza A, Bifulco G, Masullo M, et al. (2010) Mutremdamide A and koshikamides C-H, peptide inhibitors of HIV-1 entry from different Theonella species. The Journal of Organic Chemistry. 75: 4344-55
Plaza A, Keffer JL, Lloyd JR, et al. (2010) Paltolides A--C, anabaenopeptin-type peptides from the palau sponge Theonella swinhoei. Journal of Natural Products. 73: 485-8
Keffer JL, Plaza A, Bewley CA. (2009) Motualevic acids A-F, antimicrobial acids from the sponge Siliquariaspongia sp. Organic Letters. 11: 1087-90
Plaza A, Bifulco G, Keffer JL, et al. (2009) Celebesides A-C and theopapuamides B-D, depsipeptides from an Indonesian sponge that inhibit HIV-1 entry. The Journal of Organic Chemistry. 74: 504-12
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