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Wei Ke, Ph.D.

Affiliations: 
2011 Biochemistry Case Western Reserve University, Cleveland Heights, OH, United States 
Area:
Biochemistry
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"Wei Ke"
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Focco van den Akker grad student 2011 Case Western
 (Mechanisms of beta-lactamase inhibition and heterotropic allosteric regulation of an engineered beta-lactamase-MBP fusion protein.)

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Publications

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Ke W, Pattanaik P, Bethel CR, et al. (2012) Structures of SHV-1 β-lactamase with penem and penam sulfone inhibitors that form cyclic intermediates stabilized by carbonyl conjugation. Plos One. 7: e49035
Ke W, Laurent AH, Armstrong MD, et al. (2012) Structure of an engineered β-lactamase maltose binding protein fusion protein: insights into heterotropic allosteric regulation. Plos One. 7: e39168
Ke W, Rodkey EA, Sampson JM, et al. (2012) The importance of the trans-enamine intermediate as a β-lactamase inhibition strategy probed in inhibitor-resistant SHV β-lactamase variants. Chemmedchem. 7: 1002-8
Ke W, Bethel CR, Papp-Wallace KM, et al. (2012) Crystal structures of KPC-2 β-lactamase in complex with 3-nitrophenyl boronic acid and the penam sulfone PSR-3-226. Antimicrobial Agents and Chemotherapy. 56: 2713-8
Sampson JM, Ke W, Bethel CR, et al. (2011) Ligand-dependent disorder of the Omega loop observed in extended-spectrum SHV-type beta-lactamase. Antimicrobial Agents and Chemotherapy. 55: 2303-9
Ke W, Sampson JM, Ori C, et al. (2011) Novel insights into the mode of inhibition of class A SHV-1 beta-lactamases revealed by boronic acid transition state inhibitors. Antimicrobial Agents and Chemotherapy. 55: 174-83
Ke W, Bethel CR, Thomson JM, et al. (2007) Crystal structure of KPC-2: insights into carbapenemase activity in class A beta-lactamases. Biochemistry. 46: 5732-40
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