Hui-Hua Chang, Ph.D.

Affiliations: 
2013 Nutritional Sciences University of Arizona, Tucson, AZ 
Area:
Pharmacology, Oncology, Biochemistry
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Parents

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Emmanuelle J. Meuillet grad student 2013 University of Arizona
 (Discovery and characterization of novel inhibitors of the prostaglandin E2 pathway.)
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Publications

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Dong TS, Chang HH, Hauer M, et al. (2019) Metformin Alters the Duodenal Microbiome and Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced Obesity. American Journal of Physiology. Gastrointestinal and Liver Physiology
Chang HH, Eibl G. (2019) Obesity-Induced Adipose Tissue Inflammation as a Strong Promotional Factor for Pancreatic Ductal Adenocarcinoma. Cells. 8
Hao F, Xu Q, Wang J, et al. (2019) Lipophilic statins inhibit YAP nuclear localization, co-activator activity and colony formation in pancreatic cancer cells and prevent the initial stages of pancreatic ductal adenocarcinoma in KrasG12D mice. Plos One. 14: e0216603
Hao F, Xu Q, Wang J, et al. (2019) Sa2010 – Lipophilic Statins Inhibit Yap Nuclear Localization, Coactivator Activity and Colony Formation in Pancreatic Cancer Cells and Prevent the Initial Stages of Pancreatic Ductal Adenocarcinoma in Kras Mice Gastroenterology. 156
Xu M, Chang HH, Jung X, et al. (2018) Deficiency in hormone-sensitive lipase accelerates the development of pancreatic cancer in conditional KrasG12D mice. Bmc Cancer. 18: 797
Kaur K, Chang HH, Topchyan P, et al. (2018) Deficiencies in Natural Killer Cell Numbers, Expansion, and Function at the Pre-Neoplastic Stage of Pancreatic Cancer by KRAS Mutation in the Pancreas of Obese Mice. Frontiers in Immunology. 9: 1229
Chang HH, Moro A, Chou CEN, et al. (2018) Metformin Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced Obesity in the Conditional KrasG12D Mouse Model. Scientific Reports. 8: 5899
Takakura K, Speakman S, Chang H, et al. (2018) Tu1343 - TP53 Determines the Effects of Beclin1 Haploinsufficiency on Autophagy and Tumorigenesis in a Kras G12D Mouse Model of Pancreatic Cancer Gastroenterology. 154: S-937
Chang H, Sinnett-Smith J, Schmidt AI, et al. (2018) Mo1988 - Metformin Prevents Kras-Mutant Pancreatic Ductal Adenocarcinoma Promoted by Diet-Induced Obesity Gastroenterology. 154: S-873
Chang H, Sinnett-Smith J, Hines OJ, et al. (2018) Metformin prevents obesity-promoted pancreatic cancer development in the conditional KrasG12D mouse model Pancreatology. 18: S153
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