David H. Goetz, Ph.D.

Affiliations: 
2002 University of Washington, Seattle, Seattle, WA 
Area:
Microbiology Biology, Molecular Biology, Immunology
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Roland K. Strong grad student 2002 University of Washington
 (Neutrophil gelatinase -associated lipocalin: A protein involved in immune defense against microbial pathogens.)
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Publications

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Lee GM, Balouch E, Goetz DH, et al. (2012) Mapping inhibitor binding modes on an active cysteine protease via nuclear magnetic resonance spectroscopy. Biochemistry. 51: 10087-98
Schneider EL, Lee MS, Baharuddin A, et al. (2012) A reverse binding motif that contributes to specific protease inhibition by antibodies. Journal of Molecular Biology. 415: 699-715
Zhou Y, Agudelo J, Lu K, et al. (2011) Inhibitors of SARS-CoV entry--identification using an internally-controlled dual envelope pseudovirion assay. Antiviral Research. 92: 187-94
Devireddy LR, Hart DO, Goetz DH, et al. (2010) A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production. Cell. 141: 1006-17
Duriseti S, Goetz DH, Hostetter DR, et al. (2010) Antagonistic anti-urokinase plasminogen activator receptor (uPAR) antibodies significantly inhibit uPAR-mediated cellular signaling and migration. The Journal of Biological Chemistry. 285: 26878-88
Ohol YM, Goetz DH, Chan K, et al. (2010) Mycobacterium tuberculosis MycP1 protease plays a dual role in regulation of ESX-1 secretion and virulence. Cell Host & Microbe. 7: 210-20
Mahon CS, O'Donoghue AJ, Goetz DH, et al. (2009) Characterization of a multimeric, eukaryotic prolyl aminopeptidase: an inducible and highly specific intracellular peptidase from the non-pathogenic fungus Talaromyces emersonii. Microbiology (Reading, England). 155: 3673-82
O'Donoghue AJ, Mahon CS, Goetz DH, et al. (2008) Inhibition of a secreted glutamic peptidase prevents growth of the fungus Talaromyces emersonii. The Journal of Biological Chemistry. 283: 29186-95
Lazic A, Goetz DH, Nomura AM, et al. (2007) Substrate modulation of enzyme activity in the herpesvirus protease family. Journal of Molecular Biology. 373: 913-23
Bell JK, Goetz DH, Mahrus S, et al. (2003) The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity. Nature Structural Biology. 10: 527-34
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