Christopher A. Jedeszko, Ph.D.

Affiliations: 
2009 Pharmacology Wayne State University, Detroit, MI, United States 
Area:
Cell Biology
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Parents

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Bonnie F. Sloane grad student 2009 Wayne State
 (Three-dimensional organotypic cultures of ductal carcinoma in situ model the effects of stroma on breast cancer progression.)
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Publications

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Jedeszko C, Paez-Ribes M, Di Desidero T, et al. (2015) Postsurgical adjuvant or metastatic renal cell carcinoma therapy models reveal potent antitumor activity of metronomic oral topotecan with pazopanib. Science Translational Medicine. 7: 282ra50
Ebos JM, Mastri M, Lee CR, et al. (2014) Neoadjuvant antiangiogenic therapy reveals contrasts in primary and metastatic tumor efficacy. Embo Molecular Medicine. 6: 1561-76
Di Matteo P, Hackl C, Jedeszko C, et al. (2013) NGR-TNF, a novel vascular-targeting agent, does not induce cytokine recruitment of proangiogenic bone marrow-derived cells. British Journal of Cancer. 109: 360-9
Caglič D, Repnik U, Jedeszko C, et al. (2013) The proinflammatory cytokines interleukin-1α and tumor necrosis factor α promote the expression and secretion of proteolytically active cathepsin S from human chondrocytes. Biological Chemistry. 394: 307-16
Matteo PD, Hackl C, Jedeszko C, et al. (2012) Abstract 4381: The novel direct-acting vascular targeting agent NGR-TNF exertsin vivoantitumor activity by inducing endothelial and tumor cell death in the absence of proangiogenic bone-marrow derived cell recruitment Cancer Research. 72: 4381-4381
Ebos JML, Lee CR, Cruz-Munoz W, et al. (2012) Abstract 1375: Contrasting effects of VEGF pathway inhibitors in primary and metastatic disease using perioperative neoadjuvant mouse models Cancer Research. 72: 1375-1375
Matteo PD, Hackl C, Jedeszko C, et al. (2011) Abstract 4249: NGR-TNF, a novel direct-acting vascular targeting agent, does not induce “cytokine-rebound” recruitment of pro-angiogenic bone-marrow derived cells Cancer Research. 71: 4249-4249
Jedeszko C, Victor BC, Podgorski I, et al. (2009) Fibroblast hepatocyte growth factor promotes invasion of human mammary ductal carcinoma in situ. Cancer Research. 69: 9148-55
Sameni M, Cavallo-Medved D, Dosescu J, et al. (2009) Imaging and quantifying the dynamics of tumor-associated proteolysis Clinical and Experimental Metastasis. 26: 299-309
Jedeszko C, Sameni M, Olive MB, et al. (2008) Visualizing protease activity in living cells: from two dimensions to four dimensions. Current Protocols in Cell Biology / Editorial Board, Juan S. Bonifacino ... [Et Al.]. Unit 4.20
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