Michael J. McLeish, Ph.D.
Affiliations: | 1988-1998 | Victorian College of Pharmacy | Monash University, Parkville, Australia |
| 1998-2008 | Medicinal Chemistry | University of Michigan, Ann Arbor, Ann Arbor, MI | |
| 2008- | Chemistry and Chemical Biology | IUPUI, Indianapolis, IN, United States |
Area:
Enzyme Mechanisms, Biochemistry, Molecular Biology,Website:
https://science.iupui.edu/ppgenchemmcleish-michaelGoogle:
"Michael J. McLeish"Bio:
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Parents
Sign in to add mentor| Trevor James Broxton | grad student | 1984 | La Trobe University | |
| (Mechanisms of the Decomposition of Aryl Diazonium Salts.) | ||||
| Jack F. Kirsch | post-doc | 1983-1984 | UC Berkeley | |
| George L. Kenyon | research scientist | 1996-1997 | UCSF | |
| (Sabbatical) | ||||
Children
Sign in to add trainee| Shivansh Mahajan | research assistant | 2016-2020 | IUPUI |
| Lidia V. Najbar | grad student | 1996 | Melbourne University |
| Michael Campbell | grad student | 1997 | Melbourne University |
| Joanne Caine | grad student | 1999 | Monash University |
| Forest H. Andrews | grad student | 2014 | Purdue |
| Alex Latta | grad student | 2019 | Purdue |
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Publications
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| Planas F, McLeish MJ, Himo F. (2019) Computational characterization of enzyme-bound thiamin diphosphate reveals a surprisingly stable tricyclic state: implications for catalysis. Beilstein Journal of Organic Chemistry. 15: 145-159 |
| Planas F, McLeish MJ, Himo F. (2019) Computational Study of Enantioselective Carboligation Catalyzed by Benzoylformate Decarboxylase Acs Catalysis. 9: 5657-5667 |
| Planas F, Sheng X, McLeish MJ, et al. (2018) A Theoretical Study of the Benzoylformate Decarboxylase Reaction Mechanism. Frontiers in Chemistry. 6: 205 |
| Pallitsch K, Rogers MP, Andrews FH, et al. (2017) Phosphonodifluoropyruvate is a mechanism-based inhibitor of phosphonopyruvate decarboxylase from Bacteroides fragilis. Bioorganic & Medicinal Chemistry |
| Zahniser MP, Prasad S, Kneen MM, et al. (2017) Structure and mechanism of benzaldehyde dehydrogenase from Pseudomonas putida ATCC 12633, a member of the Class 3 aldehyde dehydrogenase superfamily. Protein Engineering, Design & Selection : Peds. 1-8 |
| Adediran SA, Wang PF, Shilabin AG, et al. (2017) Specificity and mechanism of mandelamide hydrolase catalysis. Archives of Biochemistry and Biophysics |
| Andrews F, Wechsler C, Rogers M, et al. (2016) Mechanistic and Structural Insight to an Evolved Benzoylformate Decarboxylase with Enhanced Pyruvate Decarboxylase Activity Catalysts. 6: 190 |
| Andrews FH, Horton JD, Shin D, et al. (2015) The kinetic characterization and X-ray structure of a putative benzoylformate decarboxylase from M. smegmatis highlights the difficulties in the functional annotation of ThDP-dependent enzymes. Biochimica Et Biophysica Acta. 1854: 1001-9 |
| Loschonsky S, Wacker T, Waltzer S, et al. (2014) Extended reaction scope of thiamine diphosphate dependent cyclohexane-1,2-dione hydrolase: from C-C bond cleavage to C-C bond ligation. Angewandte Chemie (International Ed. in English). 53: 14402-6 |
| Andrews FH, Rogers MP, Paul LN, et al. (2014) Perturbation of the monomer-monomer interfaces of the benzoylformate decarboxylase tetramer. Biochemistry. 53: 4358-67 |