Michael J. McLeish, Ph.D.
|1988-1998||Victorian College of Pharmacy||Monash University, Parkville, Australia|
|1998-2008||Medicinal Chemistry||University of Michigan, Ann Arbor, Ann Arbor, MI|
|2008-||Chemistry and Chemical Biology||IUPUI, Indianapolis, IN, United States|
Area:Enzyme Mechanisms, Biochemistry, Molecular Biology,
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|Lu J, Bart AG, Wu Q, et al. (2020) Structure-Based Drug Design of Bisubstrate Inhibitors of Phenylethanolamine -Methyltransferase Possessing Low Nanomolar Affinity at Both Substrate Binding Domains. Journal of Medicinal Chemistry|
|Planas F, McLeish MJ, Himo F. (2019) Computational characterization of enzyme-bound thiamin diphosphate reveals a surprisingly stable tricyclic state: implications for catalysis. Beilstein Journal of Organic Chemistry. 15: 145-159|
|Planas F, Sheng X, McLeish MJ, et al. (2018) A Theoretical Study of the Benzoylformate Decarboxylase Reaction Mechanism. Frontiers in Chemistry. 6: 205|
|Pallitsch K, Rogers MP, Andrews FH, et al. (2017) Phosphonodifluoropyruvate is a mechanism-based inhibitor of phosphonopyruvate decarboxylase from Bacteroides fragilis. Bioorganic & Medicinal Chemistry|
|Zahniser MP, Prasad S, Kneen MM, et al. (2017) Structure and mechanism of benzaldehyde dehydrogenase from Pseudomonas putida ATCC 12633, a member of the Class 3 aldehyde dehydrogenase superfamily. Protein Engineering, Design & Selection : Peds. 1-8|
|Adediran SA, Wang PF, Shilabin AG, et al. (2017) Specificity and mechanism of mandelamide hydrolase catalysis. Archives of Biochemistry and Biophysics|
|Andrews FH, Horton JD, Shin D, et al. (2015) The kinetic characterization and X-ray structure of a putative benzoylformate decarboxylase from M. smegmatis highlights the difficulties in the functional annotation of ThDP-dependent enzymes. Biochimica Et Biophysica Acta. 1854: 1001-9|
|Loschonsky S, Wacker T, Waltzer S, et al. (2014) Extended reaction scope of thiamine diphosphate dependent cyclohexane-1,2-dione hydrolase: from C-C bond cleavage to C-C bond ligation. Angewandte Chemie (International Ed. in English). 53: 14402-6|
|Andrews FH, Rogers MP, Paul LN, et al. (2014) Perturbation of the monomer-monomer interfaces of the benzoylformate decarboxylase tetramer. Biochemistry. 53: 4358-67|
|Patel H, Nemeria NS, Andrews FH, et al. (2014) Identification of charge transfer transitions related to thiamin-bound intermediates on enzymes provides a plethora of signatures useful in mechanistic studies. Biochemistry. 53: 2145-52|