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Michael J. McLeish, Ph.D.

1988-1998 Victorian College of Pharmacy Monash University, Parkville, Australia 
 1998-2008 Medicinal Chemistry University of Michigan, Ann Arbor, Ann Arbor, MI 
 2008- Chemistry and Chemical Biology IUPUI, Indianapolis, IN, United States 
Enzyme Mechanisms, Biochemistry, Molecular Biology,
"Michael J. McLeish"

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Trevor James Broxton grad student 1984 La Trobe University
 (Mechanisms of the Decomposition of Aryl Diazonium Salts.)
Jack F. Kirsch post-doc 1983-1984 UC Berkeley
George L. Kenyon research scientist 1996-1997 UCSF


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Lidia V. Najbar grad student 1996 Melbourne University
Michael Campbell grad student 1997 Melbourne University
Joanne Caine grad student 1999 Monash University
Forest H. Andrews grad student 2014 Purdue
Alex Latta grad student 2019 Purdue
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Lu J, Bart AG, Wu Q, et al. (2020) Structure-Based Drug Design of Bisubstrate Inhibitors of Phenylethanolamine -Methyltransferase Possessing Low Nanomolar Affinity at Both Substrate Binding Domains. Journal of Medicinal Chemistry
Planas F, McLeish MJ, Himo F. (2019) Computational characterization of enzyme-bound thiamin diphosphate reveals a surprisingly stable tricyclic state: implications for catalysis. Beilstein Journal of Organic Chemistry. 15: 145-159
Planas F, Sheng X, McLeish MJ, et al. (2018) A Theoretical Study of the Benzoylformate Decarboxylase Reaction Mechanism. Frontiers in Chemistry. 6: 205
Pallitsch K, Rogers MP, Andrews FH, et al. (2017) Phosphonodifluoropyruvate is a mechanism-based inhibitor of phosphonopyruvate decarboxylase from Bacteroides fragilis. Bioorganic & Medicinal Chemistry
Zahniser MP, Prasad S, Kneen MM, et al. (2017) Structure and mechanism of benzaldehyde dehydrogenase from Pseudomonas putida ATCC 12633, a member of the Class 3 aldehyde dehydrogenase superfamily. Protein Engineering, Design & Selection : Peds. 1-8
Adediran SA, Wang PF, Shilabin AG, et al. (2017) Specificity and mechanism of mandelamide hydrolase catalysis. Archives of Biochemistry and Biophysics
Andrews FH, Horton JD, Shin D, et al. (2015) The kinetic characterization and X-ray structure of a putative benzoylformate decarboxylase from M. smegmatis highlights the difficulties in the functional annotation of ThDP-dependent enzymes. Biochimica Et Biophysica Acta. 1854: 1001-9
Loschonsky S, Wacker T, Waltzer S, et al. (2014) Extended reaction scope of thiamine diphosphate dependent cyclohexane-1,2-dione hydrolase: from C-C bond cleavage to C-C bond ligation. Angewandte Chemie (International Ed. in English). 53: 14402-6
Andrews FH, Rogers MP, Paul LN, et al. (2014) Perturbation of the monomer-monomer interfaces of the benzoylformate decarboxylase tetramer. Biochemistry. 53: 4358-67
Patel H, Nemeria NS, Andrews FH, et al. (2014) Identification of charge transfer transitions related to thiamin-bound intermediates on enzymes provides a plethora of signatures useful in mechanistic studies. Biochemistry. 53: 2145-52
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