Fraser Soares, Ph.D.

Affiliations: 
2014 Laboratory Medicine and Pathobiology University of Toronto, Toronto, ON, Canada 
Area:
Cell Biology, Immunology, Biochemistry
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"Fraser Soares"
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Stephen E. Girardin grad student 2014 University of Toronto
 (NLRX1 is a mitochondrial matrix protein that links cell death with tumorigenesis.)
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Publications

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Killackey SA, Bi Y, Soares F, et al. (2022) Mitochondrial protein import stress regulates the LC3 lipidation step of mitophagy through NLRX1 and RRBP1. Molecular Cell
Killackey SA, Rahman MA, Soares F, et al. (2018) The mitochondrial Nod-like receptor NLRX1 modifies apoptosis through SARM1. Molecular and Cellular Biochemistry
Motta V, Soares F, Sun T, et al. (2015) NOD-like receptors: versatile cytosolic sentinels. Physiological Reviews. 95: 149-78
Soares F, Tattoli I, Rahman MA, et al. (2014) The mitochondrial protein NLRX1 controls the balance between extrinsic and intrinsic apoptosis. The Journal of Biological Chemistry. 289: 19317-30
Frirdich E, Vermeulen J, Biboy J, et al. (2014) Peptidoglycan LD-carboxypeptidase Pgp2 influences Campylobacter jejuni helical cell shape and pathogenic properties and provides the substrate for the DL-carboxypeptidase Pgp1. The Journal of Biological Chemistry. 289: 8007-18
Soares F, Tattoli I, Wortzman ME, et al. (2013) NLRX1 does not inhibit MAVS-dependent antiviral signalling. Innate Immunity. 19: 438-48
Ling A, Soares F, Croitoru DO, et al. (2012) Post-transcriptional inhibition of luciferase reporter assays by the Nod-like receptor proteins NLRX1 and NLRC3. The Journal of Biological Chemistry. 287: 28705-16
Tattoli I, Sorbara MT, Vuckovic D, et al. (2012) Amino acid starvation induced by invasive bacterial pathogens triggers an innate host defense program. Cell Host & Microbe. 11: 563-75
Limbergen JV, Soares F, Russell RK, et al. (2012) CROHN'S DISEASE ASSOCIATED NOD2 VARIANTS SHOW DIFFERENTIAL ACTIVATION OF NF-kappa B IN RESPONSE TO AUTO-SIGNALLING AND MURAMYL DIPEPTIDE Gut. 61
Van Limbergen J, Soares F, Russell RK, et al. (2012) Sa1996 Crohn's Disease Associated NOD2 Variants Show Differential Activation of NFkB in Response to Autosignaling and Muramyl Dipeptide Gastroenterology. 142: S-377
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