Mathieu Coincon, Ph.D.
Affiliations: | 2010 | Université de Montréal, Montréal, Canada |
Area:
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Parents
Sign in to add mentor| Jurgen Sygusch | grad student | 2010 | Université de Montréal | |
| (Etude structure-fonction des fructose-1,6-bisphosphate aldolases metallo-dependantes: Mecanisme catalytique et developpement d'antimicrobiens.) | ||||
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Publications
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| Jacques B, Coinçon M, Sygusch J. (2018) Active site remodeling during the catalytic cycle in metal-dependent fructose-1,6-bisphosphate aldolases. The Journal of Biological Chemistry |
| Mohanty B, Rimmer K, McMahon RM, et al. (2017) Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1. Plos One. 12: e0173436 |
| Tanner JE, Coinçon M, Leblond V, et al. (2015) Peptides designed to spatially depict the Epstein-Barr virus major virion glycoprotein gp350 neutralization epitope elicit antibodies that block virus-neutralizing antibody 72A1 interaction with the native gp350 molecule. Journal of Virology. 89: 4932-41 |
| Smith MA, Coinçon M, Paschos A, et al. (2012) Identification of the binding site of Brucella VirB8 interaction inhibitors. Chemistry & Biology. 19: 1041-8 |
| Coincon M, Wang W, Sygusch J, et al. (2012) Crystal structure of reaction intermediates in pyruvate class II aldolase: substrate cleavage, enolate stabilization, and substrate specificity. The Journal of Biological Chemistry. 287: 36208-21 |
| de la Paz Santangelo M, Gest PM, Guerin ME, et al. (2011) Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli. The Journal of Biological Chemistry. 286: 40219-31 |
| Daher R, Coinçon M, Fonvielle M, et al. (2010) Rational design, synthesis, and evaluation of new selective inhibitors of microbial class II (zinc dependent) fructose bis-phosphate aldolases. Journal of Medicinal Chemistry. 53: 7836-42 |
| Starnes GL, Coincon M, Sygusch J, et al. (2009) Aldolase is essential for energy production and bridging adhesin-actin cytoskeletal interactions during parasite invasion of host cells. Cell Host & Microbe. 5: 353-64 |
| Fonvielle M, Coinçon M, Daher R, et al. (2008) Synthesis and biochemical evaluation of selective inhibitors of class II fructose bisphosphate aldolases: towards new synthetic antibiotics. Chemistry (Weinheim An Der Bergstrasse, Germany). 14: 8521-9 |
| Dax C, Duffieux F, Chabot N, et al. (2006) Selective irreversible inhibition of fructose 1,6-bisphosphate aldolase from Trypanosoma brucei. Journal of Medicinal Chemistry. 49: 1499-502 |