Nichole Coleman, Ph.D.

2014 Chemistry University of California, Davis, Davis, CA 
Organic Chemistry, Medicine and Surgery
"Nichole Coleman"
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Heike Wulff grad student 2014 UC Davis
 (The Design, Synthesis and Functional in-vivo Evaluation of Potent and Selective Small Molecules Targeting KCa Channels.)
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Oliván-Viguera A, Valero MS, Pinilla E, et al. (2016) Vascular reactivity profile of novel KC a 3.1-selective positive-gating modulators in the coronary vascular bed. Basic & Clinical Pharmacology & Toxicology
Oliván-Viguera A, Valero MS, Coleman N, et al. (2015) A novel pan-negative-gating modulator of KCa2/3 channels, fluoro-di-benzoate, RA-2, inhibits endothelium-derived hyperpolarization-type relaxation in coronary artery and produces bradycardia in vivo. Molecular Pharmacology. 87: 338-48
Coleman N, Nguyen HM, Cao Z, et al. (2015) The riluzole derivative 2-amino-6-trifluoromethylthio-benzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel anticonvulsant. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 12: 234-49
Coleman N, Brown BM, Oliván-Viguera A, et al. (2014) New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1. Molecular Pharmacology. 86: 342-57
Lam J, Coleman N, Garing AL, et al. (2013) The therapeutic potential of small-conductance KCa2 channels in neurodegenerative and psychiatric diseases. Expert Opinion On Therapeutic Targets. 17: 1203-20
Strøbæk D, Brown DT, Jenkins DP, et al. (2013) NS6180, a new K(Ca) 3.1 channel inhibitor prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease. British Journal of Pharmacology. 168: 432-44
Bodendiek SB, Rubinos C, Trelles MP, et al. (2012) Triarylmethanes, a new class of cx50 inhibitors. Frontiers in Pharmacology. 3: 106
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