Kim L.R. Brouwer
Affiliations: | 1986- | Pharmaceutical Sciences | University of North Carolina, Chapel Hill, Chapel Hill, NC |
Area:
Pharmaceutical ChemistryWebsite:
https://pharmacy.unc.edu/news/directory/kbrouwer/Google:
"Kim Brouwer"Bio:
http://pharmacy.uky.edu/news/brouwer-receive-pharmaceutical-sciences-outstanding-alumni-award
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Parents
Sign in to add mentor| Robert A. Blouin | grad student | 1983 | University of Kentucky | |
| Harry Barr Kostenbauder | grad student | 1983 | University of Kentucky | |
| (Alterations in Phenobarbital Pharmacokinetics and Enzyme Induction in a Genetically Obese Rodent Model.) | ||||
| Mary Edith Vore | post-doc | 1986 | University of Kentucky | |
Children
Sign in to add trainee| Priyamvada Chandra | grad student | 2004 | UNC Chapel Hill |
| Keith A. Hoffmaster | grad student | 2004 | UNC Chapel Hill |
| Ryan Z. Turncliff | grad student | 2004 | UNC Chapel Hill |
| Giulia Ghibellini | grad student | 2006 | UNC Chapel Hill |
| Maciej J. Zamek-Gliszczynski | grad student | 2006 | UNC Chapel Hill |
| Tracy L. Marion | grad student | 2011 | UNC Chapel Hill |
| Zhixia Yan | grad student | 2011 | UNC Chapel Hill |
| Scott J. Brantley | grad student | 2013 | UNC Chapel Hill |
| David R. Taft | post-doc | 1993-1994 | UNC Chapel Hill |
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Publications
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| Saran C, Sundqvist L, Ho H, et al. (2021) Novel Bile Acid-dependent Mechanisms of Hepatotoxicity Associated with Tyrosine Kinase Inhibitors. The Journal of Pharmacology and Experimental Therapeutics |
| Ito K, Sjöstedt N, Malinen MM, et al. (2020) Hepatic Transporter Alterations by Nuclear Receptor Agonist T0901317 in Sandwich-cultured Human Hepatocytes: Proteomic Analysis and PBPK Modeling to Evaluate Drug-Drug Interaction Risk. The Journal of Pharmacology and Experimental Therapeutics |
| Brouwer K. (2020) S5.3 - Transporters in polycystic kidney disease Drug Metabolism and Pharmacokinetics. 35 |
| Bezencon J, Beaudoin JJ, Ito K, et al. (2019) Altered Expression and Function of Hepatic Transporters in a Rodent Model of Polycystic Kidney Disease. Drug Metabolism and Disposition: the Biological Fate of Chemicals |
| Brouwer K. (2019) Transporters and drug-induced liver injury Drug Metabolism and Pharmacokinetics. 34: S5 |
| Ito K, Brouwer KL. (2018) LXR/FXR agonist alters transporter expression in sandwich-cultured human hepatocytes; proteomics-driven PBPK modeling implicates a drug–drug interaction with metformin Drug Metabolism and Pharmacokinetics. 33: S88 |
| Brouwer KL. (2018) The role of hepatic transporters in drug disposition and elimination Drug Metabolism and Pharmacokinetics. 33: S2 |
| Ali I, Welch MA, Lu Y, et al. (2017) Identification of novel MRP3 inhibitors based on computational models and validation using an in vitro membrane vesicle assay. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences |
| Woodhead JL, Brock WJ, Roth SE, et al. (2016) Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors. Toxicological Sciences : An Official Journal of the Society of Toxicology |
| Wells MA, Vendrov KC, Edin ML, et al. (2016) Characterization of the Cytochrome P450 Epoxyeicosanoid Pathway in Non-alcoholic Steatohepatitis. Prostaglandins & Other Lipid Mediators |