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Wenwei Lin, Ph.D.

Affiliations: 
2006 University of Tennessee Health Science Center, Memphis, TN, United States 
Area:
Pharmaceutical Chemistry
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John K. Buolamwini grad student 2006 UTHSC
 (Studies on dipyridamole and draflazine analogs as inhibitors of human equilibrative nucleoside transporters hENT1 and hENT2.)

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Publications

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Huber AD, Poudel S, Wu J, et al. (2023) A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR. Nucleic Acids Research
Li Y, Lin W, Chai SC, et al. (2022) Design and Optimization of 1-1,2,3-Triazole-4-carboxamides as Novel, Potent, and Selective Inverse Agonists and Antagonists of PXR. Journal of Medicinal Chemistry. 65: 16829-16859
Li Y, Lin W, Wright WC, et al. (2021) Building a Chemical Toolbox for Human Pregnane X Receptor Research: Discovery of Agonists, Inverse Agonists, and Antagonists Among Analogs Based on the Unique Chemical Scaffold of SPA70. Journal of Medicinal Chemistry
Huber AD, Wright WC, Lin W, et al. (2020) Mutation of a single amino acid of pregnane X receptor switches an antagonist to agonist by altering AF-2 helix positioning. Cellular and Molecular Life Sciences : Cmls
Lin W, Bwayi M, Wu J, et al. (2019) CITCO Directly Binds to and Activates Human Pregnane X Receptor. Molecular Pharmacology
Chai SC, Lin W, Li Y, et al. (2019) Drug discovery technologies to identify and characterize modulators of the pregnane X receptor and the constitutive androstane receptor. Drug Discovery Today
Ippagunta SK, Pollock JA, Sharma N, et al. (2018) Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins. Science Signaling. 11
Chang Y, Woessner DW, Lin W, et al. (2018) Abstract IA12: Modeling and targeting CREBBP mutations in relapsed acute lymphoblastic leukemia Cancer Research. 78
Roberts KG, Yang YL, Payne-Turner D, et al. (2017) Oncogenic role and therapeutic targeting of ABL-class and JAK-STAT activating kinase alterations in Ph-like ALL. Blood Advances. 1: 1657-1671
Pitre A, Ge Y, Lin W, et al. (2017) An unexpected protein interaction promotes drug resistance in leukemia. Nature Communications. 8: 1547
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