Gyan P. Modi, Ph.D.
Affiliations: | 2013 | Pharmaceutical Sciences | Wayne State University, Detroit, MI, United States |
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Sign in to add mentor| Aloke Dutta | grad student | 2013 | Wayne State | |
| (Design, synthesis, biological evaluation and molecular modeling studies of novel multifunctional neuroprotective drugs for the treatment of Parkinson's disease: An effort towards the improvement of in vivo efficacy and modulation of alpha synuclein aggre) | ||||
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| Singh YP, Tej GNVC, Pandey A, et al. (2020) Design, synthesis and biological evaluation of novel naturally-inspired multifunctional molecules for the management of Alzheimer's disease. European Journal of Medicinal Chemistry. 198: 112257 |
| Singh SK, Dutta A, Modi G. (2017) α-Synuclein aggregation modulation: an emerging approach for the treatment of Parkinson's disease. Future Medicinal Chemistry |
| Das B, Modi G, Dutta A. (2015) Dopamine D3 agonists in the treatment of Parkinson's disease. Current Topics in Medicinal Chemistry. 15: 908-26 |
| Modi G, Sharma H, Kharkar PS, et al. (2014) Understanding the Structural Requirements of Hybrid (S)-6-((2-(4-Phenylpiperazin-1-yl)ethyl)(propyl)amino)-5,6,7,8-tetrahydronaphthalen-1-ol and its Analogs as D2/D3 Receptor Ligands: A Three-Dimensional Quantitative Structure-Activity Relationship (3D QSAR) Investigation. Medchemcomm. 5: 1384-1399 |
| Modi G, Voshavar C, Gogoi S, et al. (2014) Multifunctional D2/D3 agonist D-520 with high in vivo efficacy: modulator of toxicity of alpha-synuclein aggregates. Acs Chemical Neuroscience. 5: 700-17 |
| Modi G, Antonio T, Reith M, et al. (2014) Structural modifications of neuroprotective anti-Parkinsonian (-)-N6-(2-(4-(biphenyl-4-yl)piperazin-1-yl)-ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine (D-264): an effort toward the improvement of in vivo efficacy of the parent molecule. Journal of Medicinal Chemistry. 57: 1557-72 |
| Shah M, Voshavar C, Xu L, et al. (2013) Evaluation of multifunctional dopamine agonists in modulation of alpha-synuclein induced aggregation and toxicity: implication in neuroprotective treatment of Parkinson's disease F1000research. 4 |
| Gogoi S, Biswas S, Modi G, et al. (2012) Novel bivalent ligands for D2/D3 dopamine receptors: Significant co-operative gain in D2 affinity and potency. Acs Medicinal Chemistry Letters. 3: 991-996 |
| Gopishetty B, Hazeldine S, Santra S, et al. (2011) Further structure-activity relationship studies on 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: identification of compounds with triple uptake inhibitory activity as potential antidepressant agents. Journal of Medicinal Chemistry. 54: 2924-32 |