Timothy B. Johnstone, Ph.D.

Affiliations: 
2002 University of California, Irvine, Irvine, CA 
Area:
Pharmacology
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"Timothy Johnstone"
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Kelvin W. Gee grad student 2002 UC Irvine
 (Elucidation of a putative novel allosteric modulatory site on the GABA(A) receptor complex.)
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Publications

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Johnstone TBC, McCarren HS, Spampanato J, et al. (2019) Enaminone Modulators of Extrasynaptic αβδ γ-Aminobutyric Acid Receptors Reverse Electrographic Status Epilepticus in the Rat After Acute Organophosphorus Poisoning. Frontiers in Pharmacology. 10: 560
Johnstone TBC, Xie JY, Qu C, et al. (2018) Positive Allosteric Modulators of Non-Benzodiazepine γ-Aminobutyric acida Receptor Subtypes for the Treatment of Chronic Pain. Pain
Reddy DS, Yoshimura RF, Ramanathan G, et al. (2018) Role of β-specific GABA-A receptor isoforms in the development of hippocampus kindling epileptogenesis. Epilepsy & Behavior : E&B. 82: 57-63
Hogenkamp DJ, Tran MB, Yoshimura RF, et al. (2014) Pharmacological profile of a 17β-heteroaryl-substituted neuroactive steroid. Psychopharmacology. 231: 3517-24
Yoshimura RF, Tran MB, Hogenkamp DJ, et al. (2014) Limited central side effects of a β-subunit subtype-selective GABAA receptor allosteric modulator. Journal of Psychopharmacology (Oxford, England). 28: 472-8
Hogenkamp DJ, Ford-Hutchinson TA, Li WY, et al. (2013) Design, synthesis, and activity of a series of arylpyrid-3-ylmethanones as type I positive allosteric modulators of α7 nicotinic acetylcholine receptors. Journal of Medicinal Chemistry. 56: 8352-65
Johnstone TB, Gu Z, Yoshimura RF, et al. (2011) Allosteric modulation of related ligand-gated ion channels synergistically induces long-term potentiation in the hippocampus and enhances cognition. The Journal of Pharmacology and Experimental Therapeutics. 336: 908-15
Gee KW, Tran MB, Hogenkamp DJ, et al. (2010) Limiting activity at beta1-subunit-containing GABAA receptor subtypes reduces ataxia. The Journal of Pharmacology and Experimental Therapeutics. 332: 1040-53
Hogenkamp DJ, Johnstone TB, Huang JC, et al. (2007) Enaminone amides as novel orally active GABAA receptor modulators. Journal of Medicinal Chemistry. 50: 3369-79
Ng HJ, Whittemore ER, Tran MB, et al. (2007) Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators. Proceedings of the National Academy of Sciences of the United States of America. 104: 8059-64
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