Heidi A. Schwanz, Ph.D.
Affiliations: | 2012 | Pharmacy | University of Iowa, Iowa City, IA |
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Sign in to add mentor| Robert J. Kerns | grad student | 2012 | University of Iowa | |
| (Structural features of fluoroquinolone-class antibiotics that affect lethal activities and DNA binding.) | ||||
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| Carter HE, Wildman B, Schwanz HA, et al. (2023) Role of the Water-Metal Ion Bridge in Quinolone Interactions with Gyrase. International Journal of Molecular Sciences. 24 |
| Malik M, Mustaev A, Schwanz HA, et al. (2016) Suppression of gyrase-mediated resistance by C7 aryl fluoroquinolones. Nucleic Acids Research |
| Oppegard LM, Schwanz HA, Towle TR, et al. (2016) Fluoroquinolones stimulate the DNA cleavage activity of topoisomerase IV by promoting the binding of Mg(2+) to the second metal binding site. Biochimica Et Biophysica Acta. 1860: 569-75 |
| Aldred KJ, Schwanz HA, Li G, et al. (2015) Activity of quinolone CP-115,955 against bacterial and human type II topoisomerases is mediated by different interactions. Biochemistry. 54: 1278-86 |
| Aldred KJ, Schwanz HA, Li G, et al. (2013) Overcoming target-mediated quinolone resistance in topoisomerase IV by introducing metal-ion-independent drug-enzyme interactions. Acs Chemical Biology. 8: 2660-8 |
| Malik M, Marks KR, Schwanz HA, et al. (2010) Effect of N-1/c-8 ring fusion and C-7 ring structure on fluoroquinolone lethality. Antimicrobial Agents and Chemotherapy. 54: 5214-21 |
| Oppegard LM, Streck KR, Rosen JD, et al. (2010) Comparison of in vitro activities of fluoroquinolone-like 2,4- and 1,3-diones. Antimicrobial Agents and Chemotherapy. 54: 3011-4 |