Stephanie A. Leavitt, Ph.D.

Affiliations: 
2006 Johns Hopkins University, Baltimore, MD 
Area:
General Biophysics
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"Stephanie Leavitt"
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Ernesto Freire grad student 2006 Johns Hopkins
 (Characterization of the allosteric mechanism of HIV-1 proteins gp120 and NEF.)
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Publications

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Velazquez-Campoy A, Leavitt SA, Freire E. (2015) Characterization of protein-protein interactions by isothermal titration calorimetry. Methods in Molecular Biology (Clifton, N.J.). 1278: 183-204
Lazerwith SE, Lew W, Zhang J, et al. (2014) Discovery of GS-9669, a thumb site II non-nucleoside inhibitor of NS5B for the treatment of genotype 1 chronic hepatitis C infection. Journal of Medicinal Chemistry. 57: 1893-901
Fenaux M, Eng S, Leavitt SA, et al. (2013) Preclinical characterization of GS-9669, a thumb site II inhibitor of the hepatitis C virus NS5B polymerase. Antimicrobial Agents and Chemotherapy. 57: 804-10
Clarke MO, Byun D, Chen X, et al. (2012) Novel, potent and orally bioavailable indolizidinone-derived inhibitors of the hepatitis C virus NS3 protease. Bioorganic & Medicinal Chemistry Letters. 22: 1095-8
Lansdon EB, Liu Q, Leavitt SA, et al. (2011) Structural and binding analysis of pyrimidinol carboxylic acid and N-hydroxy quinazolinedione HIV-1 RNase H inhibitors. Antimicrobial Agents and Chemotherapy. 55: 2905-15
Callebaut C, Stray K, Tsai L, et al. (2011) In vitro characterization of GS-8374, a novel phosphonate-containing inhibitor of HIV-1 protease with a favorable resistance profile. Antimicrobial Agents and Chemotherapy. 55: 1366-76
Khaki AR, Field C, Malik S, et al. (2010) The macroscopic rate of nucleic acid translocation by hepatitis C virus helicase NS3h is dependent on both sugar and base moieties. Journal of Molecular Biology. 400: 354-78
Cihlar T, He GX, Liu X, et al. (2006) Suppression of HIV-1 protease inhibitor resistance by phosphonate-mediated solvent anchoring. Journal of Molecular Biology. 363: 635-47
Bacha U, Barrila J, Velazquez-Campoy A, et al. (2004) Identification of novel inhibitors of the SARS coronavirus main protease 3CLpro. Biochemistry. 43: 4906-12
Velazquez-Campoy A, Leavitt SA, Freire E. (2004) Characterization of protein-protein interactions by isothermal titration calorimetry. Methods in Molecular Biology (Clifton, N.J.). 261: 35-54
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