Adam J. Ruben, Ph.D.
Affiliations: | 2008 | Johns Hopkins University, Baltimore, MD |
Area:
Molecular Biology, Microbiology Biology, General BiophysicsGoogle:
"Adam Ruben"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Ernesto Freire | grad student | 2008 | Johns Hopkins | |
| (Adaptive Plasmepsin inhibitors as novel antimalarials.) | ||||
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Publications
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| Miura T, Hidaka K, Uemura T, et al. (2010) Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution. Bioorganic & Medicinal Chemistry Letters. 20: 4836-9 |
| Hidaka K, Kimura T, Ruben AJ, et al. (2009) Erratum to “Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin” [Bioorg. Med. Chem. 16 (2008) 10049–10060] Bioorganic & Medicinal Chemistry. 17: 1772 |
| Hidaka K, Kimura T, Ruben AJ, et al. (2008) Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorganic & Medicinal Chemistry. 16: 10049-60 |
| Hidaka K, Kimura T, Tsuchiya Y, et al. (2007) Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II. Bioorganic & Medicinal Chemistry Letters. 17: 3048-52 |
| Ruben AJ, Kiso Y, Freire E. (2006) Overcoming roadblocks in lead optimization: a thermodynamic perspective. Chemical Biology & Drug Design. 67: 2-4 |