Usman M. Bacha, Ph.D.
Affiliations: | 2008 | Johns Hopkins University, Baltimore, MD |
Area:
General Biophysics, Biochemistry, PharmacologyGoogle:
"Usman Bacha"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Ernesto Freire | grad student | 2008 | Johns Hopkins | |
| (Development of inhibitors against the SARS coronaviral protease 3CLpro.) | ||||
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Publications
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| Barrila J, Gabelli SB, Bacha U, et al. (2010) Mutation of Asn28 disrupts the dimerization and enzymatic activity of SARS 3CL(pro) . Biochemistry. 49: 4308-17 |
| Regnier T, Sarma D, Hidaka K, et al. (2009) New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CL(pro) inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 2722-7 |
| Bacha U, Barrila J, Gabelli SB, et al. (2008) Development of broad-spectrum halomethyl ketone inhibitors against coronavirus main protease 3CL(pro). Chemical Biology & Drug Design. 72: 34-49 |
| Brower ET, Bacha UM, Kawasaki Y, et al. (2008) Inhibition of HIV-2 protease by HIV-1 protease inhibitors in clinical use. Chemical Biology & Drug Design. 71: 298-305 |
| Sydnes MO, Hayashi Y, Sharma VK, et al. (2006) Synthesis of glutamic acid and glutamine peptides possessing a trifluoromethyl ketone group as SARS-CoV 3CL protease inhibitors. Tetrahedron. 62: 8601-8609 |
| Barrila J, Bacha U, Freire E. (2006) Long-range cooperative interactions modulate dimerization in SARS 3CLpro. Biochemistry. 45: 14908-16 |
| Bacha U, Barrila J, Velazquez-Campoy A, et al. (2004) Identification of novel inhibitors of the SARS coronavirus main protease 3CLpro. Biochemistry. 43: 4906-12 |
| Velázquez-Campoy A, Vega S, Fleming E, et al. (2003) Protease inhibition in African subtypes of HIV-1. Aids Reviews. 5: 165-71 |