Jennifer A. Barrila, Ph.D.
Affiliations: | 2009 | Johns Hopkins University, Baltimore, MD |
Area:
Medical Biophysics, General BiophysicsGoogle:
"Jennifer Barrila"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Ernesto Freire | grad student | 2009 | Johns Hopkins | |
| (Dimerization of the SARS coronavirus 3CL protease is controlled through long-range interactions.) | ||||
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Publications
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| Barrila J, Gabelli SB, Bacha U, et al. (2010) Mutation of Asn28 disrupts the dimerization and enzymatic activity of SARS 3CL(pro) . Biochemistry. 49: 4308-17 |
| Bacha U, Barrila J, Gabelli SB, et al. (2008) Development of broad-spectrum halomethyl ketone inhibitors against coronavirus main protease 3CL(pro). Chemical Biology & Drug Design. 72: 34-49 |
| Sydnes MO, Hayashi Y, Sharma VK, et al. (2006) Synthesis of glutamic acid and glutamine peptides possessing a trifluoromethyl ketone group as SARS-CoV 3CL protease inhibitors. Tetrahedron. 62: 8601-8609 |
| Barrila J, Bacha U, Freire E. (2006) Long-range cooperative interactions modulate dimerization in SARS 3CLpro. Biochemistry. 45: 14908-16 |
| Nadella M, Bianchet MA, Gabelli SB, et al. (2005) Structure and activity of the axon guidance protein MICAL. Proceedings of the National Academy of Sciences of the United States of America. 102: 16830-5 |
| Bacha U, Barrila J, Velazquez-Campoy A, et al. (2004) Identification of novel inhibitors of the SARS coronavirus main protease 3CLpro. Biochemistry. 43: 4906-12 |