Karunya K. Kandimalla, Ph.D.

Affiliations: 
2004 University of Iowa, Iowa City, IA 
Area:
Pharmacy, Neuroscience Biology
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Maureen D. Donovan grad student 2004 University of Iowa
 (Carrier mediated transport of small molecules across bovine nasal mucosae: Implications in nose -to -brain drug delivery.)
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Publications

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Wang Z, Sharda N, Omtri RS, et al. (2023) . Molecular Pharmacology
Wang Z, Sharda N, Curran GL, et al. (2021) Semimechanistic Population Pharmacokinetic Modeling to Investigate Amyloid Beta Trafficking and Accumulation at the BBB Endothelium. Molecular Pharmaceutics. 18: 4148-4161
Sharda N, Ahlschwede KM, Curran GL, et al. (2020) Distinct uptake kinetics of Alzheimer's disease amyloid beta 40 and 42 at the blood-brain barrier endothelium. The Journal of Pharmacology and Experimental Therapeutics
Swaminathan SK, Zhou AL, Ahlschwede KM, et al. (2020) HDL mimetic peptide 4F efficiently crosses the blood-brain barrier and modulates amyloid beta distribution between brain and plasma. The Journal of Pharmacology and Experimental Therapeutics
Sharda N, Pengo T, Wang Z, et al. (2020) Amyloid-β Peptides Disrupt Interactions Between VAMP-2 and SNAP-25 in Neuronal Cells as Determined by FRET/FLIM. Journal of Alzheimer's Disease : Jad
Gali CC, Fanaee-Danesh E, Zandl-Lang M, et al. (2019) Amyloid-beta impairs insulin signaling by accelerating autophagy-lysosomal degradation of LRP-1 and IR-β in blood-brain barrier endothelial cells in vitro and in 3XTg-AD mice. Molecular and Cellular Neurosciences. 103390
Zhou AL, Swaminathan SK, Curran GL, et al. (2019) Apolipoprotein A-I crosses the blood-brain barrier through clathrin-independent and cholesterol-mediated endocytosis. The Journal of Pharmacology and Experimental Therapeutics
Ahlschwede KM, Curran GL, Rosenberg JT, et al. (2018) Cationic carrier peptide enhances cerebrovascular targeting of nanoparticles in Alzheimer's disease brain. Nanomedicine : Nanotechnology, Biology, and Medicine
Chernick D, Ortiz-Valle S, Jeong A, et al. (2018) HDL Mimetic Peptide 4F Mitigates Aβ-Induced Inhibition of ApoE Secretion and Lipidation in Primary Astrocytes and Microglia. Journal of Neurochemistry
Swaminathan SK, Ahlschwede KM, Sarma V, et al. (2017) Insulin differentially affects the distribution kinetics of amyloid beta 40 and 42 in plasma and brain. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X17709709
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