Delaine K. Ceholski, Ph.D.

Affiliations: 
2012 Biochemistry University of Alberta, Edmonton, Alberta, Canada 
Area:
Biochemistry
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"Delaine Ceholski"
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Howard S. Young grad student 2012 University of Alberta
 (Molecular insights into the disease-causing mechanisms of human phospholamban mutations.)
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Publications

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Raad N, Bittihn P, Cacheux M, et al. (2021) Arrhythmia Mechanism and Dynamics in a Humanized Mouse Model of Inherited Cardiomyopathy Due to Phospholamban R14del Mutation. Circulation
Gorski PA, Ceholski DK, Young HS. (2017) Structure-Function Relationship of the SERCA Pump and Its Regulation by Phospholamban and Sarcolipin. Advances in Experimental Medicine and Biology. 981: 77-119
Young HS, Ceholski DK, Trieber CA. (2015) Deception in simplicity: hereditary phospholamban mutations in dilated cardiomyopathy. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 93: 1-7
Abrol N, Smolin N, Armanious G, et al. (2014) Phospholamban C-terminal residues are critical determinants of the structure and function of the calcium ATPase regulatory complex. The Journal of Biological Chemistry. 289: 25855-66
Abrol N, Smolin N, Ceholski DK, et al. (2014) Phospholamban C-Terminal Truncations Including Heart Failure Mutation L39Stop Decrease Membrane Localization and Oligomerization and Alter the Structure of the PLB-Serca Complex Biophysical Journal. 106: 566a-567a
Ceholski DK, Trieber CA, Holmes CF, et al. (2012) Lethal, hereditary mutants of phospholamban elude phosphorylation by protein kinase A. The Journal of Biological Chemistry. 287: 26596-605
Ceholski DK, Trieber CA, Young HS. (2012) Hydrophobic imbalance in the cytoplasmic domain of phospholamban is a determinant for lethal dilated cardiomyopathy. The Journal of Biological Chemistry. 287: 16521-9
Glaves JP, Trieber CA, Ceholski DK, et al. (2011) Phosphorylation and mutation of phospholamban alter physical interactions with the sarcoplasmic reticulum calcium pump. Journal of Molecular Biology. 405: 707-23
Glaves JP, Trieber CA, Ceholski DK, et al. (2011) Phosphorylation and Mutation Induce an Order-To-Disorder Transition in the Cytoplasmic Domain of Phospholamban Biophysical Journal. 100: 343a-344a
Afara MR, Trieber CA, Ceholski DK, et al. (2008) Peptide inhibitors use two related mechanisms to alter the apparent calcium affinity of the sarcoplasmic reticulum calcium pump. Biochemistry. 47: 9522-30
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