Aaron M. LeBeau, Ph.D.

Affiliations: 
2009 Johns Hopkins University, Baltimore, MD 
Area:
Pharmacology, Biochemistry, Oncology
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Parents

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Samuel R. Denmeade grad student 2009 Johns Hopkins
 (The rational design of peptidyl based inhibitors of prostate-specific antigen.)
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Publications

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Page MJ, Lourenço AL, David T, et al. (2015) Non-invasive imaging and cellular tracking of pulmonary emboli by near-infrared fluorescence and positron-emission tomography. Nature Communications. 6: 8448
LeBeau AM, Sevillano N, Markham K, et al. (2015) Imaging active urokinase plasminogen activator in prostate cancer. Cancer Research. 75: 1225-35
LeBeau AM, Denmeade SR. (2015) Protease-activated pore-forming peptides for the treatment and imaging of prostate cancer. Molecular Cancer Therapeutics. 14: 659-68
LeBeau AM, Sevillano N, King ML, et al. (2014) Imaging the urokinase plasminongen activator receptor in preclinical breast cancer models of acquired drug resistance. Theranostics. 4: 267-79
LeBeau AM, Duriseti S, Murphy ST, et al. (2013) Targeting uPAR with antagonistic recombinant human antibodies in aggressive breast cancer. Cancer Research. 73: 2070-81
LeBeau AM, Lee M, Murphy ST, et al. (2013) Imaging a functional tumorigenic biomarker in the transformed epithelium. Proceedings of the National Academy of Sciences of the United States of America. 110: 93-8
Duriseti S, Goetz DH, Hostetter DR, et al. (2010) Antagonistic anti-urokinase plasminogen activator receptor (uPAR) antibodies significantly inhibit uPAR-mediated cellular signaling and migration. The Journal of Biological Chemistry. 285: 26878-88
LeBeau AM, Kostova M, Craik CS, et al. (2010) Prostate-specific antigen: an overlooked candidate for the targeted treatment and selective imaging of prostate cancer. Biological Chemistry. 391: 333-43
Singh P, LeBeau AM, Lilja H, et al. (2009) Molecular insights into substrate specificity of prostate specific antigen through structural modeling. Proteins. 77: 984-93
LeBeau AM, Banerjee SR, Pomper MG, et al. (2009) Optimization of peptide-based inhibitors of prostate-specific antigen (PSA) as targeted imaging agents for prostate cancer. Bioorganic & Medicinal Chemistry. 17: 4888-93
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