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Linyi Wei, Ph.D.

Affiliations: 
2006 University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Pharmaceutical Chemistry
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Kuo-Hsiung Lee grad student 2006 UNC Chapel Hill
 (New tylophorine analogs as potential antitumor agents.)

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Liu N, Wei L, Huang L, et al. (2016) Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitor Agents: Optimization of Diarylanilines with High Potency against Wild-Type and Rilpivirine-Resistant E138K Mutant Virus. Journal of Medicinal Chemistry
Chen CY, Yang SC, Lee KH, et al. (2014) The antitumor agent PBT-1 directly targets HSP90 and hnRNP A2/B1 and inhibits lung adenocarcinoma growth and metastasis. Journal of Medicinal Chemistry. 57: 677-85
Lin JC, Yang SC, Hong TM, et al. (2009) Phenanthrene-based tylophorine-1 (PBT-1) inhibits lung cancer cell growth through the Akt and NF-kappaB pathways. Journal of Medicinal Chemistry. 52: 1903-11
Gao W, Chen AP, Leung CH, et al. (2008) Structural analogs of tylophora alkaloids may not be functional analogs. Bioorganic & Medicinal Chemistry Letters. 18: 704-9
Wei L, Brossi A, Morris-Natschke SL, et al. (2008) Antitumor agents 248. Chemistry and antitumor activity of tylophorinerelated alkaloids Studies in Natural Products Chemistry. 34: 3-34
Wei L, Shi Q, Bastow KF, et al. (2007) Antitumor agents 253. Design, synthesis, and antitumor evaluation of novel 9-substituted phenanthrene-based tylophorine derivatives as potential anticancer agents. Journal of Medicinal Chemistry. 50: 3674-80
Zhang S, Wei L, Bastow K, et al. (2007) Antitumor agents 252. Application of validated QSAR models to database mining: discovery of novel tylophorine derivatives as potential anticancer agents. Journal of Computer-Aided Molecular Design. 21: 97-112
Wei L, Brossi A, Kendall R, et al. (2006) Antitumor agents 251: synthesis, cytotoxic evaluation, and structure-activity relationship studies of phenanthrene-based tylophorine derivatives (PBTs) as a new class of antitumor agents. Bioorganic & Medicinal Chemistry. 14: 6560-9
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