☰

John C. Kalvass, Ph.D.

Affiliations: 
2006 University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Pharmacy, Pharmacology
Google:
"John Kalvass"
Mean distance: (not calculated yet)
 
Tree Publications Similar researchers PubMed Report error

Parents

Sign in to add mentor
Gary M. Pollack grad student 2006 UNC Chapel Hill
 (Prediction of brain extracellular fluid concentrations: Application to understanding central nervous system pharmacokinetics and pharmacodynamics.)

Children

Sign in to add trainee

Collaborators

Sign in to add collaborator
BETA: Related publications

Publications

You can help our author matching system! If you notice any publications incorrectly attributed to this author, please sign in and mark matches as correct or incorrect.

Kikuchi R, de Morais SM, Kalvass JC. (2013) In vitro P-glycoprotein efflux ratio can predict the in vivo brain penetration regardless of biopharmaceutics drug disposition classification system class. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 2012-7
Kalvass JC, Polli JW, Bourdet DL, et al. (2013) Why clinical modulation of efflux transport at the human blood-brain barrier is unlikely: the ITC evidence-based position. Clinical Pharmacology and Therapeutics. 94: 80-94
Zhao R, Kalvass JC, Pollack GM. (2009) Assessment of blood-brain barrier permeability using the in situ mouse brain perfusion technique. Pharmaceutical Research. 26: 1657-64
Zhao R, Kalvass JC, Yanni SB, et al. (2009) Fexofenadine brain exposure and the influence of blood-brain barrier P-glycoprotein after fexofenadine and terfenadine administration. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 529-35
Zamek-Gliszczynski MJ, Kalvass JC, Pollack GM, et al. (2009) Relationship between drug/metabolite exposure and impairment of excretory transport function. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 386-90
Kielbasa W, Kalvass JC, Stratford R. (2009) Microdialysis evaluation of atomoxetine brain penetration and central nervous system pharmacokinetics in rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 137-42
Kalvass JC, Olson ER, Cassidy MP, et al. (2007) Pharmacokinetics and pharmacodynamics of seven opioids in P-glycoprotein-competent mice: assessment of unbound brain EC50,u and correlation of in vitro, preclinical, and clinical data. The Journal of Pharmacology and Experimental Therapeutics. 323: 346-55
Kalvass JC, Maurer TS, Pollack GM. (2007) Use of plasma and brain unbound fractions to assess the extent of brain distribution of 34 drugs: comparison of unbound concentration ratios to in vivo p-glycoprotein efflux ratios. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 660-6
Kalvass JC, Pollack GM. (2007) Kinetic considerations for the quantitative assessment of efflux activity and inhibition: implications for understanding and predicting the effects of efflux inhibition. Pharmaceutical Research. 24: 265-76
Kalvass JC, Olson ER, Pollack GM. (2007) Pharmacokinetics and pharmacodynamics of alfentanil in P-glycoprotein-competent and P-glycoprotein-deficient mice: P-glycoprotein efflux alters alfentanil brain disposition and antinociception. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 455-9
See more...