Malcolm J. Low, M.D., Ph.D

Affiliations: 
Oregon Health and Science University, Portland, OR 
 Molecular & Integrative Physiology and Metabolism, Endocrinology & Diabetes University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
obesity, diabetes, hypothalamus
Website:
https://www.umms.med.umich.edu/pibsfacsearch/facultyPage.do?facUniqname=mjlow
Google:
"Malcolm Low"
Mean distance: 15.74 (cluster 52)
 
SNBCP
Cross-listing: Neurotree

Parents

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Ronald M. Lechan grad student Tufts Medical Center (Neurotree)
Richard H. Goodman post-doc OHSU (Neurotree)

Children

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James Smart grad student 2004 OHSU (Neurotree)
Shane T. Hentges post-doc OHSU (Neurotree)
Marcelo Rubinstein post-doc OHSU
Daniel D. Lam post-doc 2010-2014 University of Michigan
Aaron Jeffrey Mercer post-doc 2011-2015 University of Michigan
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Publications

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Yu H, Rubinstein M, Low MJ. (2022) Developmental single-cell transcriptomics of hypothalamic POMC neurons reveal the genetic trajectories of multiple neuropeptidergic phenotypes. Elife. 11
Surbhi, Wittmann G, Low MJ, et al. (2021) Adult-born proopiomelanocortin neurons derived from Rax-expressing precursors mitigate the metabolic effects of congenital hypothalamic proopiomelanocortin deficiency. Molecular Metabolism. 101312
Shakya M, Gahlot S, White A, et al. (2021) Mice lacking PC1/3 expression in POMC-expressing cells do not develop obesity. Endocrinology
Na ES, Lam DD, Yokosawa E, et al. (2020) Decreased sensitivity to the anorectic effects of leptin in mice that lack a Pomc-specific neural enhancer. Plos One. 15: e0244793
Hael CE, Rojo D, Orquera DP, et al. (2020) The transcriptional regulator PRDM12 is critical for Pomc expression in the mouse hypothalamus and controlling food intake, adiposity, and body weight. Molecular Metabolism. 34: 43-53
Yu H, Thompson Z, Kiran S, et al. (2020) Expression of a hypomorphic Pomc allele alters leptin dynamics during late pregnancy. The Journal of Endocrinology
Gahlot S, Wittmann G, Lechan RM, et al. (2020) OR16-03 Metabolic Effects Of Hypothalamic Pomc Neurons Generated Postnatally From Tanycytes On A Pomc Null Genetic Background Journal of the Endocrine Society. 4
Yu H, Jones G, Thompson Z, et al. (2020) MON-709 Single-Cell RNA-Sequencing Deciphers POMC Neuron Destiny Journal of the Endocrine Society. 4
Jones GL, Wittmann G, Yokosawa EB, et al. (2019) Selective Restoration of Expression in Glutamatergic POMC Neurons: Evidence for a Dynamic Hypothalamic Neurotransmitter Network. Eneuro. 6
Orquera DP, Tavella MB, de Souza FSJ, et al. (2019) The homeodomain transcription factor NKX2.1 is essential for the early specification of melanocortin neuron identity and activates expression in the developing hypothalamus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience
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