Jerry P. Melchor, Ph.D.

Affiliations: 
2001 Stony Brook University, Stony Brook, NY, United States 
Area:
Neuroscience Biology, Cell Biology
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William E. Van Nostrand grad student 2001 SUNY Stony Brook
 (Pathogenic interactions between the amyloid beta-protein and cerebrovascular smooth muscle cells.)
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Publications

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Paul J, Strickland S, Melchor JP. (2007) Fibrin deposition accelerates neurovascular damage and neuroinflammation in mouse models of Alzheimer's disease. The Journal of Experimental Medicine. 204: 1999-2008
Melchor JP, Pawlak R, Strickland S. (2003) The tissue plasminogen activator-plasminogen proteolytic cascade accelerates amyloid-beta (Abeta) degradation and inhibits Abeta-induced neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8867-71
Melchor JP, Pawlak R, Chen Z, et al. (2003) The possible role of tissue-type plasminogen activator (tPA) and tPA blockers in the pathogenesis and treatment of Alzheimer's disease. Journal of Molecular Neuroscience : Mn. 20: 287-9
Melchor JP, Pawlak R, Strickland S. (2003) The Tissue Plasminogen Activator-Plasminogen Proteolytic Cascade Accelerates Amyloid-β (Aβ) Degradation and Inhibits Aβ-Induced Neurodegeneration The Journal of Neuroscience. 23: 8867-8871
Van Nostrand WE, Melchor JP, Romanov G, et al. (2002) Pathogenic effects of cerebral amyloid angiopathy mutations in the amyloid beta-protein precursor. Annals of the New York Academy of Sciences. 977: 258-65
Van Nostrand WE, Melchor JP, Keane DM, et al. (2002) Localization of a fibrillar amyloid beta-protein binding domain on its precursor. The Journal of Biological Chemistry. 277: 36392-8
Van Nostrand WE, Melchor JP. (2001) Disruption of pathologic amyloid beta-protein fibril assembly on the surface of cultured human cerebrovascular smooth muscle cells. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 8: 20-7
Van Nostrand WE, Melchor JP, Cho HS, et al. (2001) Pathogenic Effects of D23N Iowa Mutant Amyloid β-Protein Journal of Biological Chemistry. 276: 32860-32866
Wagner MR, Keane DM, Melchor JP, et al. (2000) Fibrillar amyloid beta-protein binds protease nexin-2/amyloid beta-protein precursor: stimulation of its inhibition of coagulation factor XIa. Biochemistry. 39: 7420-7
Van Nostrand WE, Melchor J, Wagner M, et al. (2000) Cerebrovascular smooth muscle cell surface fibrillar aβ Annals of the New York Academy of Sciences. 903: 89-96
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