Vincent J. Colandrea, Ph.D.

2002 Rutgers University, New Brunswick, New Brunswick, NJ, United States 
Organic Chemistry
"Vincent Colandrea"
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Leslie S. Jimenez grad student 2002 Rutgers, New Brunswick
 (I. Progress toward the synthesis of mitomycin C. II. Synthesis and reactions of C(2)-symmetric vinylsulfonium salts.)
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Wilson JE, Kurukulasuriya R, Reibarkh M, et al. (2016) Discovery of Novel Indoline Cholesterol Ester Transfer Protein Inhibitors (CETP) through a Structure-Guided Approach. Acs Medicinal Chemistry Letters. 7: 261-5
Neelamkavil SF, Agrawal S, Bara T, et al. (2016) Discovery of MK-8831, A Novel Spiro-Proline Macrocycle as a Pan-Genotypic HCV-NS3/4a Protease Inhibitor. Acs Medicinal Chemistry Letters. 7: 111-6
Vachal P, Miao S, Pierce JM, et al. (2012) 1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia. Journal of Medicinal Chemistry. 55: 2945-59
Yan L, Colandrea VJ, Hale JJ. (2010) Prolyl hydroxylase domain-containing protein inhibitors as stabilizers of hypoxia-inducible factor: small molecule-based therapeutics for anemia. Expert Opinion On Therapeutic Patents. 20: 1219-45
Du W, Jewell JP, Lin LS, et al. (2009) Synthesis and evaluation of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-aminopropanamide as human cannabinoid-1 receptor (CB1R) inverse agonists. Bioorganic & Medicinal Chemistry Letters. 19: 5195-9
Armstrong HE, Galka A, Lin LS, et al. (2007) Substituted acyclic sulfonamides as human cannabinoid-1 receptor inverse agonists. Bioorganic & Medicinal Chemistry Letters. 17: 2184-7
Colandrea VJ, Legiec IE, Huo P, et al. (2006) 2,5-Disubstituted pyrrolidine carboxylates as potent, orally active sphingosine-1-phosphate (S1P) receptor agonists. Bioorganic & Medicinal Chemistry Letters. 16: 2905-8
Colandrea VJ, Rajaraman S, Jimenez LS. (2003) Synthesis of the mitomycin and FR900482 ring systems via dimethyldioxirane oxidation. Organic Letters. 5: 785-7
Stearns RA, Miller RR, Tang W, et al. (2002) The pharmacokinetics of a thiazole benzenesulfonamide beta 3-adrenergic receptor agonist and its analogs in rats, dogs, and monkeys: improving oral bioavailability. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 30: 771-7
Biftu T, Feng DD, Liang GB, et al. (2000) Synthesis and SAR of benzyl and phenoxymethylene oxadiazole benzenesulfonamides as selective beta3 adrenergic receptor agonist antiobesity agents. Bioorganic & Medicinal Chemistry Letters. 10: 1431-4
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