Henk Timmerman

Affiliations: 
Pharmacochemistry Vrije Universiteit Amsterdam, Amsterdam, Netherlands 
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"Henk Timmerman"
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Wybe Th. Nauta grad student 1967 Free University of Amsterdam
 (2-alkyl-1-[ortho-alkyl-phenyl] cyclohexanols, synthesis, conformation and some pharmacological investigations)
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Publications

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Kooistra AJ, de Graaf C, Timmerman H. (2014) The receptor concept in 3D: from hypothesis and metaphor to GPCR-ligand structures. Neurochemical Research. 39: 1850-61
Malan SF, van Marle A, Menge WM, et al. (2012) Corrigendum to “Fluorescent ligands for the histamine H2 receptor: Synthesis and preliminary characterization” [Bioorg. Med. Chem. 12 (2004) 6495–6503 Bioorganic & Medicinal Chemistry. 20: 6003
Wijtmans M, Denonne F, Célanire S, et al. (2010) Histamine H3 receptor ligands with a 3-cyclobutoxy motif: A novel and versatile constraint of the classical 3-propoxy linker Medchemcomm. 1: 39-44
van Muijlwijk-Koezen JE, Timmerman H, van der Sluis RP, et al. (2010) ChemInform Abstract: Synthesis and Use of FSCPX, an Irreversible Adenosine A1 Antagonist, as a “Receptor Knock-Down” Tool. Cheminform. 32: no-no
Célanire S, Wijtmans M, Christophe B, et al. (2009) Discovery of a new class of non-imidazole oxazoline-based histamine H(3) receptor (H(3)R) inverse agonists. Chemmedchem. 4: 1063-8
Wijtmans M, Celanire S, Snip E, et al. (2008) 4-benzyl-1H-imidazoles with oxazoline termini as histamine H3 receptor agonists. Journal of Medicinal Chemistry. 51: 2944-53
Bakker RA, Jongejan A, Sansuk K, et al. (2008) Constitutively active mutants of the histamine H1 receptor suggest a conserved hydrophobic asparagine-cage that constrains the activation of class A G protein-coupled receptors. Molecular Pharmacology. 73: 94-103
Storelli S, Verzijl D, Al-Badie J, et al. (2007) Synthesis and structure-activity relationships of 3H-quinazolin-4-ones and 3H-pyrido[2,3-d]pyrimidin-4-ones as CXCR3 receptor antagonists. Archiv Der Pharmazie. 340: 281-91
Bakker RA, Nicholas MW, Smith TT, et al. (2007) In vitro pharmacology of clinically used central nervous system-active drugs as inverse H(1) receptor agonists. The Journal of Pharmacology and Experimental Therapeutics. 322: 172-9
Dai H, Fu Q, Shen Y, et al. (2007) The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons. European Journal of Pharmacology. 563: 117-23
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