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Nico P.E. Vermeulen

Vrije Universiteit Amsterdam, Amsterdam, Netherlands 
Molecular Toxicology
"Nico Vermeulen"
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Douwe D. Breimer grad student 1980 Leiden
 (The epoxide-diol pathway in the metabolism of hexobarbital and related barbiturates : studies on the disposition of vinyl substituted barbiturates in man and rat, using capillary gas chromatography with nitrogen-selective and mass spectrometric detection)
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den Braver MW, Vermeulen NP, Commandeur JN. (2017) Generic method for the absolute quantification of glutathione S-conjugates: Application to the conjugates of acetaminophen, clozapine and diclofenac. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1046: 185-194
Dekker SJ, Zhang Y, Vos JC, et al. (2016) Different Reactive Metabolites of Nevirapine Require Distinct Glutathione S-Transferase Isoforms for Bioinactivation. Chemical Research in Toxicology. 29: 2136-2144
Zhang Y, Vermeulen NP, Commandeur JN. (2016) Characterization of human cytochrome P450 mediated bioactivation of amodiaquine and its major metabolite N-desethylamodiaquine. British Journal of Clinical Pharmacology
den Braver MW, Zhang Y, Venkataraman H, et al. (2016) Simulation of interindividual differences in inactivation of reactive para-benzoquinone imine metabolites of diclofenac by glutathione S-transferases in human liver cytosol. Toxicology Letters
den Braver MW, den Braver-Sewradj SP, Vermeulen NP, et al. (2016) Characterization of cytochrome P450 isoforms involved in sequential two-step bioactivation of diclofenac to reactive p-benzoquinone imines. Toxicology Letters. 253: 46-54
den Braver-Sewradj SP, den Braver MW, Vermeulen NP, et al. (2016) Inter-donor variability of phase I/phase II metabolism of three reference drugs in cryopreserved primary human hepatocytes in suspension and monolayer. Toxicology in Vitro : An International Journal Published in Association With Bibra
Capoferri L, Leth R, Ter Haar E, et al. (2016) Insights into regioselective metabolism of mefenamic acid by Cytochrome P450 BM3 mutants through crystallography, docking, molecular dynamics, and free energy calculations. Proteins
Reinen J, Postma G, Tump C, et al. (2016) Application of a cocktail approach to screen cytochrome P450 BM3 libraries for metabolic activity and diversity. Analytical and Bioanalytical Chemistry
Capoferri L, Verkade-Vreeker MC, Buitenhuis D, et al. (2015) Linear Interaction Energy Based Prediction of Cytochrome P450 1A2 Binding Affinities with Reliability Estimation. Plos One. 10: e0142232
Reinen J, Nematollahi L, Fidder A, et al. (2015) Characterization of human cytochrome P450s involved in the bioactivation of tri-ortho-cresyl phosphate (ToCP). Chemical Research in Toxicology. 28: 711-21
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