Mehran Jalaie, Ph.D.

Affiliations: 
2000 Purdue University, West Lafayette, IN, United States 
Area:
Physical Chemistry
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"Mehran Jalaie"
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Parents

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Kenny B. Lipkowitz grad student 2000 Purdue
 (Atomistic modeling in tribology.)
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Publications

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Cheng H, Nair SK, Murray BW, et al. (2016) Discovery of 1-{(3R,4R)-3-[5-Chloro-2-(1-methyl-1H-pyrazol-4-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxymethyl]-4-methoxy-pyrrolidin-1-yl}propenone (PF-06459988), A Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants. Journal of Medicinal Chemistry
Guo C, Linton A, Jalaie M, et al. (2013) Discovery of 2-((1H-benzo[d]imidazol-1-yl)methyl)-4H-pyrido[1,2-a]pyrimidin-4-ones as novel PKM2 activators. Bioorganic & Medicinal Chemistry Letters. 23: 3358-63
Casimiro-Garcia A, Heemstra RJ, Bigge CF, et al. (2013) Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ. Bioorganic & Medicinal Chemistry Letters. 23: 767-72
Cui JJ, McTigue M, Nambu M, et al. (2012) Discovery of a novel class of exquisitely selective mesenchymal-epithelial transition factor (c-MET) protein kinase inhibitors and identification of the clinical candidate 2-(4-(1-(quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol (PF-04217903) for the treatment of cancer. Journal of Medicinal Chemistry. 55: 8091-109
Casimiro-Garcia A, Filzen GF, Flynn D, et al. (2011) Discovery of a series of imidazo[4,5-b]pyridines with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ. Journal of Medicinal Chemistry. 54: 4219-33
Raymond JW, Holsworth DD, Jalaie M. (2011) The flexible alignment of molecular structures using simulated annealing with weighted Lagrangian multipliers. Journal of Computational Chemistry. 32: 210-7
Chen H, Zientek M, Jalaie M, et al. (2009) Characterization of cytochrome P450-mediated bioactivation of a compound containing the chemical scaffold, 4,5-dihydropyrazole-1-carboxylic acid-(4-chlorophenyl amide), to a chemically reactive p-chlorophenyl isocyanate intermediate in human liver microsomes. Chemical Research in Toxicology. 22: 1603-12
Holsworth DD, Jalaie M. (2008) Targeted inhibition of hedgehog signaling by cyclopamine prodrugs for advanced prostate cancer Chemtracts. 21: 155-160
Powell NA, Ciske FL, Cai C, et al. (2007) Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors. Bioorganic & Medicinal Chemistry. 15: 5912-49
Holsworth DD, Jalaie M, Belliotti T, et al. (2007) Discovery of 6-ethyl-2,4-diaminopyrimidine-based small molecule renin inhibitors. Bioorganic & Medicinal Chemistry Letters. 17: 3575-80
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