Daniel Bryan Goodman

Massachusetts Institute of Technology, Cambridge, MA, United States 
Synthetic Biology, Systems Biology, DNA Synthesis, Functional Genomics
"Daniel Goodman"
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Pavel A. Pevzner research assistant 2006-2009 UCSD (Neurotree)
Abraham P. Lee grad student UC Irvine (BME Tree)
Simon Tavare grad student European Bioinformatics Institute and CRUK CI (MathTree)
George  M. Church grad student 2010-2016 Harvard
Jeffrey A. Bluestone post-doc 2017- UCSF (Cell Biology Tree)
Alexander Marson post-doc 2017- UCSF
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Chang CR, Vykunta VS, Goodman DB, et al. (2024) Ultra-high efficiency T cell reprogramming at multiple loci with SEED-Selection. Biorxiv : the Preprint Server For Biology
Blaeschke F, Chen YY, Apathy R, et al. (2023) Modular pooled discovery of synthetic knockin sequences to program durable cell therapies. Cell. 186: 4216-4234.e33
Christmas MJ, Kaplow IM, Genereux DP, et al. (2023) Evolutionary constraint and innovation across hundreds of placental mammals. Science (New York, N.Y.). 380: eabn3943
Goodman DB, Azimi CS, Kearns K, et al. (2022) Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies. Science Translational Medicine. 14: eabm1463
Bucktrout SL, Banovich NE, Butterfield LH, et al. (2022) Advancing T cell-based cancer therapy with single-cell technologies. Nature Medicine. 28: 1761-1764
Schubert MG, Goodman DB, Wannier TM, et al. (2021) High-throughput functional variant screens via in vivo production of single-stranded DNA. Proceedings of the National Academy of Sciences of the United States of America. 118
Roth TL, Li PJ, Blaeschke F, et al. (2020) Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies. Cell
Nguyen DN, Roth TL, Li PJ, et al. (2019) Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency. Nature Biotechnology
Cheung R, Insigne KD, Yao D, et al. (2018) A Multiplexed Assay for Exon Recognition Reveals that an Unappreciated Fraction of Rare Genetic Variants Cause Large-Effect Splicing Disruptions. Molecular Cell
Chan Y, Chan YK, Goodman DB, et al. (2018) Enabling multiplexed testing of pooled donor cells through whole-genome sequencing. Genome Medicine. 10: 31
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