Tycho H. Heimbach, Ph.D.

Affiliations: 
2003 University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Pharmacy, Pharmaceutical Chemistry
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Gordon L. Flynn grad student 2003 University of Michigan
 (Oral phosphate prodrugs: Absorption rate limit considerations.)
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Publications

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Wu F, Mousa Y, Jereb R, et al. (2024) Using Mechanistic Modeling Approaches to Support Bioequivalence Assessments for Oral Products. The Aaps Journal. 26: 19
Tsakalozou E, Mohamed MF, Polak S, et al. (2023) Applications of Modeling and Simulation Approaches in Support of Drug Product Development of Oral Dosage Forms and Locally Acting Drug Products: a Symposium Summary. The Aaps Journal. 25: 96
Bauer A, Berben P, Chakravarthi SS, et al. (2023) Current State and Opportunities with Long-acting Injectables: Industry Perspectives from the Innovation and Quality Consortium "Long-Acting Injectables" Working Group. Pharmaceutical Research
Wu F, Mousa Y, Raines K, et al. (2022) Regulatory Utility of Physiologically Based Pharmacokinetic Modeling to Support Alternative Bioequivalence Approaches and Risk Assessment: A Workshop Summary Report. Cpt: Pharmacometrics & Systems Pharmacology
Wu D, Sanghavi M, Kollipara S, et al. (2022) Physiologically Based Pharmacokinetics Modeling in Biopharmaceutics: Case Studies for Establishing the Bioequivalence Safe Space for Innovator and Generic Drugs. Pharmaceutical Research
Lin W, Chen Y, Unadkat JD, et al. (2022) Applications, Challenges, and Outlook for PBPK Modeling and Simulation: A Regulatory, Industrial and Academic Perspective. Pharmaceutical Research
Aburub A, Chen Y, Chung J, et al. (2022) An IQ Consortium Perspective on Connecting Dissolution Methods to In Vivo Performance: Analysis of an Industrial Database and Case Studies to Propose a Workflow. The Aaps Journal. 24: 49
Laisney M, Heimbach T, Mueller-Zsigmondy M, et al. (2022) Physiologically Based Biopharmaceutics Modeling to Demonstrate Virtual Bioequivalence and Bioequivalence Safe-space for Ribociclib which has Permeation Rate-controlled Absorption. Journal of Pharmaceutical Sciences. 111: 274-284
Heimbach T, Kesisoglou F, Novakovic J, et al. (2021) Establishing the Bioequivalence Safe Space for Immediate-Release Oral Dosage Forms Using Physiologically Based Biopharmaceutics Modeling (PBBM): Case Studies. Journal of Pharmaceutical Sciences
Jogiraju VK, Heimbach T, Toderika Y, et al. (2020) Physiologically based pharmacokinetic modeling of altered tizanidine systemic exposure by CYP1A2 modulation: Impact of drug-drug interactions and cigarette consumption. Drug Metabolism and Pharmacokinetics. 37: 100375
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