Damien Y. Duveau, Ph.D.

Affiliations: 
2006 University of Louisville, Louisville, KY, United States 
Area:
Organic Chemistry
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Frederick A. Luzzio grad student 2006 University of Louisville
 (Enzymatic resolution of the 1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane system. Synthesis of 5-hydroxy-3-phthalimidoglutarimide, a metabolite of thalidomide isolated from human plasma.)
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Publications

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Itkonen HM, Gorad SS, Duveau DY, et al. (2016) Inhibition of O-GlcNAc transferase activity reprograms prostate cancer cell metabolism. Oncotarget
Ortiz-Meoz RF, Jiang J, Lazarus MB, et al. (2015) A small molecule that inhibits OGT activity in cells. Acs Chemical Biology. 10: 1392-7
Zhang M, Griner LAM, Ju W, et al. (2015) Selective targeting of JAK/STAT signaling is potentiated by Bcl-xL blockade in IL-2-dependent adult T-cell leukemia Proceedings of the National Academy of Sciences of the United States of America. 112: 12480-12485
Mathews Griner LA, Guha R, Shinn P, et al. (2014) High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells. Proceedings of the National Academy of Sciences of the United States of America. 111: 2349-54
Shukla S, Chufan EE, Singh S, et al. (2014) Elucidation of the structural basis of interaction of the BCR-ABL kinase inhibitor, nilotinib (Tasigna) with the human ABC drug transporter P-glycoprotein. Leukemia. 28: 961-4
Duveau DY, Yasgar A, Wang Y, et al. (2014) Structure-activity relationship studies and biological characterization of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors. Bioorganic & Medicinal Chemistry Letters. 24: 630-5
Duveau DY, Hu X, Walsh MJ, et al. (2013) Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 682-6
Duveau DY, Arce PM, Schoenfeld RA, et al. (2010) Synthesis and characterization of mitoQ and idebenone analogues as mediators of oxygen consumption in mitochondria. Bioorganic & Medicinal Chemistry. 18: 6429-41
Luzzio FA, Wlodarczyk MT, Duveau DY, et al. (2007) Preparation of β-phenylnitroethanes having electron-donating aryl substitution Tetrahedron Letters. 48: 6704-6708
Luzzio FA, Ott JP, Duveau DY. (2006) Radical-induced cyclopentannulation of Henry (nitroaldol)-derived intermediates. The Journal of Organic Chemistry. 71: 5027-30
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