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Thomas C. Bruice

Affiliations: 
University of California, Santa Barbara, Santa Barbara, CA, United States 
Area:
bioorganic and bioinorganic chemistry
Website:
http://www.chem.ucsb.edu/~tcb_group/tcb.htm
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"Thomas C. Bruice"
Bio:

http://www.nasonline.org/member-directory/members/57295.html

Mean distance: 7.33
 
SNBCP

Parents

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Norman Kharasch grad student 1954 USC
 (Synthesis and evaluation of thyroxine-analogues)

Collaborators

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Rafik Karaman collaborator 1989-1992 Al-Quds University
 (Post-doc)
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Publications

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Jain ML, Bruice PY, Szabó IE, et al. (2012) Incorporation of positively charged linkages into DNA and RNA backbones: a novel strategy for antigene and antisense agents. Chemical Reviews. 112: 1284-309
Awad AM, Collazo MJ, Carpio K, et al. (2012) A convenient synthesis of the cytidyl 3′-terminal monomer for solid-phase synthesis of RNG oligonucleotides Tetrahedron Letters. 53: 3792-3794
Park M, Bruice TC. (2010) Development of potential anticancer agents that target the telomere sequence. Bioorganic & Medicinal Chemistry Letters. 20: 3982-6
Luo J, Bruice TC. (2009) Envisioning the loop movements and rotation of the two subdomains of dihydrofolate reductase by elastic normal mode analysis. Journal of Biomolecular Structure & Dynamics. 27: 245-58
Park M, Bruice TC. (2008) Binding properties of positively charged deoxynucleic guanidine (DNG), AgTgAgTgAgT and DNG/DNA chimeras to DNA. Bioorganic & Medicinal Chemistry Letters. 18: 3488-91
Zhang X, Bruice TC. (2008) Product specificity and mechanism of protein lysine methyltransferases: insights from the histone lysine methyltransferase SET8. Biochemistry. 47: 6671-7
Zhang X, Bruice TC. (2008) Enzymatic mechanism and product specificity of SET-domain protein lysine methyltransferases. Proceedings of the National Academy of Sciences of the United States of America. 105: 5728-32
Park M, Canzio D, Bruice TC. (2008) Incorporation of positively charged ribonucleic guanidine linkages into oligodeoxyribonucleotides: Development of potent antisense agents. Bioorganic & Medicinal Chemistry Letters. 18: 2377-84
Zhang X, Bruice TC. (2008) Mechanism of product specificity of AdoMet methylation catalyzed by lysine methyltransferases: transcriptional factor p53 methylation by histone lysine methyltransferase SET7/9. Biochemistry. 47: 2743-8
Zhang X, Bruice TC. (2008) Complexation of single strand telomere and telomerase RNA template polyanions by deoxyribonucleic guanidine (DNG) polycations: plausible anticancer agents. Bioorganic & Medicinal Chemistry Letters. 18: 665-9
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