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Islam R. Younis, Ph.D.

Affiliations: 
2008 West Virginia University, Morgantown, WV, United States 
Area:
Pharmacology
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"Islam Younis"
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Patrick S. Callery grad student 2008 West Virginia University
 (In vitro elucidation of the metabolic fate of the anticancer drug busulfan.)

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Younis IR, George DJ, McManus TJ, et al. (2014) Clinical pharmacology of an atrasentan and docetaxel regimen in men with hormone-refractory prostate cancer. Cancer Chemotherapy and Pharmacology. 73: 991-7
Peer CJ, Younis IR, Leonard SS, et al. (2012) Glutathione conjugation of busulfan produces a hydroxyl radical-trapping dehydroalanine metabolite. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 42: 1170-7
Younis IR, Stamatakis MK, Callery PS, et al. (2009) Influence of pH on the dissolution of folic acid supplements. International Journal of Pharmaceutics. 367: 97-102
Younis IR, Elliott M, Peer CJ, et al. (2008) Dehydroalanine analog of glutathione: an electrophilic busulfan metabolite that binds to human glutathione S-transferase A1-1. The Journal of Pharmacology and Experimental Therapeutics. 327: 770-6
Cooper AJ, Younis IR, Niatsetskaya ZV, et al. (2008) Metabolism of the cysteine S-conjugate of busulfan involves a beta-lyase reaction. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 1546-52
Peer CJ, Shakleya DM, Younis IR, et al. (2007) Direct-injection mass spectrometric method for the rapid identification of fentanyl and norfentanyl in postmortem urine of six drug-overdose cases. Journal of Analytical Toxicology. 31: 515-21
Sanga M, Younis IR, Tirumalai PS, et al. (2006) Epoxidation of the methamphetamine pyrolysis product, trans-phenylpropene, to trans-phenylpropylene oxide by CYP enzymes and stereoselective glutathione adduct formation. Toxicology and Applied Pharmacology. 211: 148-56
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