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Robert Heinz Abeles, Ph.D.

Affiliations: 
1957-1960 Ohio State University, Columbus, Columbus, OH 
 1960-1964 University of Michigan, Ann Arbor, Ann Arbor, MI 
 1964-2000 Brandeis University, Waltham, MA, United States 
Area:
mechanistic enzymology
Website:
https://www.acsmedchem.org/?nd=Abeles
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"Robert H. Abeles"
Bio:

(1926 - 2000)
http://www.nasonline.org/member-directory/deceased-members/58405.html

Mean distance: 6.77
 		SNBCP
Cross-listing: MichiganTree

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Parents

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Cosmo G. Mackenzie grad student 1955 CU Boulder
 (The enzymatic oxidation of sarcosine-N-methyl-D3)
Frank H. Westheimer post-doc 1957 Harvard

Children

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Lizbeth Hedstrom grad student Brandeis (Cell Biology Tree)
Perry A. Frey grad student 1968 Brandeis
Gary Rudnick grad student 1969-1973 Brandeis
Karen N. Allen grad student 1984-1989 Brandeis
Robert A. Arkowitz grad student 1986-1991 Brandeis (Cell Biology Tree)
Gary Frey grad student 2000 Brandeis
Bruce A. Averill post-doc Brandeis
Ronald H. Kluger post-doc 1969-1970 Brandeis
Christopher T. Walsh post-doc 1970-1972 Brandeis
Richard B. Silverman post-doc 1974-1976 Brandeis
JoAnne Stubbe post-doc 1975-1977 Brandeis
Michael H. Gelb post-doc 1985 Brandeis
Barbara Imperiali post-doc 1986 Brandeis
Pradipsinh K. Rathod post-doc 1982-1986 Brandeis

Collaborators

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Publications

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Huang X, Knoell CT, Frey G, et al. (2001) Modulation of recombinant human prostate-specific antigen: activation by Hofmeister salts and inhibition by azapeptides. Appendix: thermodynamic interpretation of the activation by concentrated salts. Biochemistry. 40: 11734-41
Dai Y, Pochapsky TC, Abeles RH. (2001) Mechanistic studies of two dioxygenases in the methionine salvage pathway of Klebsiella pneumoniae. Biochemistry. 40: 6379-87
Dai Y, Hedstrom L, Abeles RH. (2000) Inactivation of cysteine proteases by (acyloxy)methyl ketones using S'-P' interactions. Biochemistry. 39: 6498-502
Govardhan CP, Abeles RH. (1996) Inactivation of cysteine proteases. Archives of Biochemistry and Biophysics. 330: 110-4
Arkowitz RA, Dhe-Paganon S, Abeles RH. (1994) The fate of the carboxyl oxygens during D-proline reduction by clostridial proline reductase. Archives of Biochemistry and Biophysics. 311: 457-9
Prorok M, Albeck A, Foxman BM, et al. (1994) Chloroketone hydrolysis by chymotrypsin and N-methylhistidyl-57-chymotrypsin: implications for the mechanism of chymotrypsin inactivation by chloroketones. Biochemistry. 33: 9784-90
Kreutter K, Steinmetz AC, Liang TC, et al. (1994) Three-dimensional structure of chymotrypsin inactivated with (2S)-N-acetyl-L-alanyl-L-phenylalanyl alpha-chloroethane: implications for the mechanism of inactivation of serine proteases by chloroketones. Biochemistry. 33: 13792-800
Dhe-Paganon S, Magrath J, Abeles RH. (1994) Mechanism of mevalonate pyrophosphate decarboxylase: evidence for a carbocationic transition state. Biochemistry. 33: 13355-62
Xu Y, Abeles RH. (1993) Inhibition of tryptophan synthase by (1-fluorovinyl)glycine. Biochemistry. 32: 806-11
Magrath J, Abeles RH. (1992) Cysteine protease inhibition by azapeptide esters. Journal of Medicinal Chemistry. 35: 4279-83
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