William H. Konigsberg

Molecular Biophysics and Biochemistry Yale University, New Haven, CT 
Blood Coagulation; DNA Replication; Genetics; Proteins and Macromolecules
"William H. Konigsberg"
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Robert R. Becker grad student 1958 Columbia
 (A study of proteins modified with N-carboxy-amino acid anydrides)
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Xia S, Wood M, Bradley MJ, et al. (2013) Alteration in the cavity size adjacent to the active site of RB69 DNA polymerase changes its conformational dynamics. Nucleic Acids Research. 41: 9077-89
Englert M, Xia S, Okada C, et al. (2012) Structural and mechanistic insights into guanylylation of RNA-splicing ligase RtcB joining RNA between 3'-terminal phosphate and 5'-OH. Proceedings of the National Academy of Sciences of the United States of America. 109: 15235-40
Xia S, Vashishtha A, Bulkley D, et al. (2012) Contribution of partial charge interactions and base stacking to the efficiency of primer extension at and beyond abasic sites in DNA. Biochemistry. 51: 4922-31
Xia S, Christian TD, Wang J, et al. (2012) Probing minor groove hydrogen bonding interactions between RB69 DNA polymerase and DNA. Biochemistry. 51: 4343-53
Xia S, Eom SH, Konigsberg WH, et al. (2012) Structural basis for differential insertion kinetics of dNMPs opposite a difluorotoluene nucleotide residue. Biochemistry. 51: 1476-85
Xia S, Eom SH, Konigsberg WH, et al. (2012) Bidentate and tridentate metal-ion coordination states within ternary complexes of RB69 DNA polymerase. Protein Science : a Publication of the Protein Society. 21: 447-51
Wang M, Xia S, Blaha G, et al. (2011) Insights into base selectivity from the 1.8 Å resolution structure of an RB69 DNA polymerase ternary complex. Biochemistry. 50: 581-90
Jiang X, Bailly MA, Panetti TS, et al. (2004) Formation of tissue factor-factor VIIa-factor Xa complex promotes cellular signaling and migration of human breast cancer cells. Journal of Thrombosis and Haemostasis : Jth. 2: 93-101
Bebenek A, Carver GT, Dressman HK, et al. (2002) Dissecting the fidelity of bacteriophage RB69 DNA polymerase: site-specific modulation of fidelity by polymerase accessory proteins. Genetics. 162: 1003-18
Lin TC, Wang CX, Joyce CM, et al. (2001) 3'-5' Exonucleolytic activity of DNA polymerases: structural features that allow kinetic discrimination between ribo- and deoxyribonucleotide residues. Biochemistry. 40: 8749-55
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