William H. Konigsberg

Affiliations: 
Molecular Biophysics and Biochemistry Yale University, New Haven, CT 
Area:
Blood Coagulation; DNA Replication; Genetics; Proteins and Macromolecules
Website:
http://medicine.yale.edu/mbb/faculty/william_konigsberg.profile
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"William H. Konigsberg"
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Parents

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Robert R. Becker grad student 1958 Columbia
 (A study of proteins modified with N-carboxy-amino acid anydrides)
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Publications

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Antonopoulos IH, Xia S, Christian TD, et al. (2016) Large α-helical movements observed in ternary crystals of RB69 DNA polymerase following nucleotide incorporation Journal of Raman Spectroscopy. 47: 110-115
Xia S, Konigsberg WH. (2014) RB69 DNA polymerase structure, kinetics, and fidelity. Biochemistry. 53: 2752-67
Xia S, Konigsberg WH. (2014) Mispairs with Watson-Crick base-pair geometry observed in ternary complexes of an RB69 DNA polymerase variant. Protein Science : a Publication of the Protein Society. 23: 508-13
Xia S, Wood M, Bradley MJ, et al. (2013) Alteration in the cavity size adjacent to the active site of RB69 DNA polymerase changes its conformational dynamics. Nucleic Acids Research. 41: 9077-89
Xia S, Wang J, Konigsberg WH. (2013) DNA mismatch synthesis complexes provide insights into base selectivity of a B family DNA polymerase. Journal of the American Chemical Society. 135: 193-202
Xia S, Vashishtha A, Bulkley D, et al. (2012) Contribution of partial charge interactions and base stacking to the efficiency of primer extension at and beyond abasic sites in DNA. Biochemistry. 51: 4922-31
Xia S, Christian TD, Wang J, et al. (2012) Probing minor groove hydrogen bonding interactions between RB69 DNA polymerase and DNA. Biochemistry. 51: 4343-53
Xia S, Eom SH, Konigsberg WH, et al. (2012) Structural basis for differential insertion kinetics of dNMPs opposite a difluorotoluene nucleotide residue. Biochemistry. 51: 1476-85
Reha-Krantz LJ, Hariharan C, Subuddhi U, et al. (2011) Structure of the 2-aminopurine-cytosine base pair formed in the polymerase active site of the RB69 Y567A-DNA polymerase. Biochemistry. 50: 10136-49
Xia S, Konigsberg WH, Wang J. (2011) Hydrogen-bonding capability of a templating difluorotoluene nucleotide residue in an RB69 DNA polymerase ternary complex. Journal of the American Chemical Society. 133: 10003-5
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