Alan Rushton Battersby

University of Cambridge, Cambridge, England, United Kingdom 
Biosynthetic pathways
"Alan Battersby"

The 1989 Wolf Prize in Chemistry: Duilio Arigoni and Alan R. Battersby for their fundamental contributions to the elucidation of the mechanism of enzymic reactions and of the biosynthesis of natural products, in particular the pigments of life.

Alan Batterby was born in 1925 and studied at the Universities of Manchester and St Andrews (PhD 1949). He gained a Commonwealth Fund Fellowship (1950-1952) for study in the United States at the Rockefeller Institute and the University of Illinois. He then joined the faculty at the University of Bristol and initiated his research in biosynthesis. In 1962 he accepted a Chair at the University of Liverpool then, in 1969, he moved to a Chair at Cambridge, finally holding the Cambridge 1702 Chair. He became Emeritus Professor in 1992 and continued both experimental research and his writing.
His research interests have been broadly concerned with the chemistry of living systems. Isolation work, structure determination, synthesis, isotope labelling and spectroscopy have been combined in these studies synergistically with enzymology and molecular biology. Three main themes can be picked out (a) biosynthesis of alkaloids (b) stereochemistry of enzyme reactions (c) biosynthesis of porphyrins and vitamin B12
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Mean distance: 7.17


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Harry Tacon Openshaw grad student 1949 University of St Andrews
 (Researches Into the Structure of Emetine)
Herbert E. Carter post-doc UIUC
Lyman C. Craig post-doc Rockefeller


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Philip A. Cole research assistant 1984-1985 Cambridge
James J De Voss grad student (Microtree)
Edmundo Rúveda grad student
Timothy John Brocksom grad student 1965-1968 University of Liverpool
Raymond C F Jones grad student 1970-1973 Cambridge
John A. Robinson grad student 1977 Cambridge
Michael D. Turnbull grad student 1974-1977 Cambridge
John Britton Campbell grad student 1975-1978 Cambridge
Keith Jones grad student 1976-1979 Cambridge
Andrew D. Hamilton grad student 1980 Cambridge
Craig J. Hawker grad student 1988 Cambridge
Jason Micklefield grad student 1993 Cambridge
Norman G. Lewis post-doc Cambridge
Mary Jane Meegan post-doc Cambridge
Murray H G Munro post-doc 1966-1968 University of Liverpool
Ronald John Parry post-doc 1968-1970 Cambridge
Wolf-Dietrich Woggon post-doc 1977-1978 Cambridge
Steven C. Zimmerman post-doc 1985 Cambridge
Andrew D. Abell post-doc 1986-1987 Cambridge
Ram A. Vishwakarma post-doc 1991-1993 Cambridge
Alan C. Spivey post-doc 1993-1995 Cambridge
Lutz Friedjan Tietze research scientist 1974 Cambridge
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Thompson S, Wilson AJ, Battersby AR. (2013) In celebration of the 60th birthday of Professor Andrew D. Hamilton FRS. Organic & Biomolecular Chemistry. 11: 6236-41
Neidhart WL, Anderson PC, Hart GJ, et al. (2010) ChemInform Abstract: Biosynthesis of Porphyrins and Related Macrocycles. Part 52. Synthesis of (11-S)-[11-2H1]Porphobilinogen and the (11R)-Enantiomer for Stereochemical Studies on Hydroxymethylbilane Synthase (Porphobilinogen Deaminase). Cheminform. 31: no-no
Ichinose K, Kodera M, Leeper FJ, et al. (2010) ChemInform Abstract: Biosynthesis of Porphyrins and Related Macrocycles. Part 51. Proof that a Reductive Step Occurs During the Biosynthesis of Vitamin B12 by the Microaerophilic Organism, Propionibacterium shermanii. Cheminform. 30: no-no
MICKLEFIELD J, BLOCK MH, BATTERSBY AR. (2010) ChemInform Abstract: Alkylation and Acylation of 5-Phenylsulfonyl- and 5-Cyanobutyrolactones. Cheminform. 24: no-no
Battersby AR. (2008) Chairman's Introduction Enzymes in Organic Synthesis. 1-2
Battersby AR, Jones K, Snow RJ. (2006) Neue Methoden zur Entmetallierung tetrapyrrolartiger Metallo-Makrocyclen Angewandte Chemie. 95: 742-743
Battersby AR. (2000) Tetrapyrroles: the pigments of life. Natural Product Reports. 17: 507-26
Hädener A, Matzinger PK, Battersby AR, et al. (1999) Determination of the structure of seleno-methionine-labelled hydroxymethylbilane synthase in its active form by multi-wavelength anomalous dispersion. Acta Crystallographica. Section D, Biological Crystallography. 55: 631-43
Ichinose K, Kodera M, Leeper FJ, et al. (1999) Biosynthesis of porphyrins and related macrocycles. Part 51.1,2 Proof that a reductive step occurs during the biosynthesis of vitamin B12 by the microaerophilic organism, Propionibacterium shermanii Journal of the Chemical Society-Perkin Transactions 1. 879-888
Abell AD, Nabbs BK, Battersby AR, et al. (1999) Synthesis and properties of ring-deactivated Deuterated (hydroxymethyl)pyrroles Chemtracts. 12: 534-538
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