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Victor J. Hruby, Ph.D.

Affiliations: 
University of Arizona, Tucson, AZ 
Area:
Organic Chemistry, Biochemistry, Chemical Biology and Medicinal Chemistry
Website:
https://cbc.arizona.edu/faculty/victor-hruby
Google:
"Victor Hruby"
Bio:

http://uacc.arizona.edu/profile/victor-hruby
https://cbc.arizona.edu/research_group/hruby_cv
http://www.americanpeptidesociety.org/awards/goodman/2011.asp

Mean distance: 9.49
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Parents

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Alfred T. Blomquist grad student 1965 Cornell
 (Some aspects of benzocyclobutene and benzocyclobutadiene chemistry)

Children

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Frederick Glenn West research assistant 1980 University of Arizona
Lauren Wugalter research assistant 2011-2013 University of Arizona
Carrie Haskell-Luevano grad student 1995 University of Arizona
Guigen Li grad student 1995 University of Arizona
Jung-Mo Ahn grad student 2000 University of Arizona
Guoxia Han grad student 2000 University of Arizona
Chaozhong Cai grad student 2001 University of Arizona
Wei Qiu grad student 2001 University of Arizona
Xue-jun Tang grad student 2002 University of Arizona
Richard S. Agnes grad student 2003 University of Arizona
Xuyuan Gu grad student 2003 University of Arizona
Chiyi Xiong grad student 2003 University of Arizona
Junyi Zhang grad student 2003 University of Arizona
Isabel M. Alves grad student 2004 University of Arizona
Minying Cai grad student 2004 University of Arizona
John M. Ndungu grad student 2004 University of Arizona
Magdalena Stankova grad student 2004 University of Arizona
Jinfa Ying grad student 2004 University of Arizona
Ravil R. Petrov grad student 2007 University of Arizona
Hongchang Qu grad student 2007 University of Arizona
Jatinder S. Josan grad student 2008 University of Arizona
Isuru R. Kumarasinghe grad student 2010 University of Arizona
James Cain grad student 2011 University of Arizona
Nabila Brabez grad student 2012 University of Arizona
Vinod V. Kulkarni grad student 2006-2012 University of Arizona
Joel B. Nyberg grad student 2013 University of Arizona
Keith M Olson grad student 2011-2017 University of Arizona (Neurotree)
Aswini Giri post-doc 2011- University of Arizona
Vinod V. Kulkarni post-doc 2011- University of Arizona
Arno F. Spatola post-doc 1971-1973 University of Arizona
Binghe Wang post-doc 1992 University of Arizona
Rajesh Sankaranarayanan post-doc 2004-2006 University of Arizona
Alexander V. Mayorov post-doc 2001-2007 University of Arizona
Srinivas Deekonda post-doc 2009-2014 University of Arizona
YeonSun Lee research scientist 2000- University of Arizona
Minying Cai research scientist 2003- University of Arizona
Ruben Vardanyan research scientist 2003- University of Arizona

Collaborators

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Tally M. Largent-Milnes collaborator 2005-2010 University of Arizona
BETA: Related publications

Publications

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Zhou Y, Mowlazadeh Haghighi S, Sawyer JR, et al. (2023) Ψ and χ Angle Constrains at the C-Terminus Trp Position of the Melanotropin Tetrapeptide Ac-His-d-Phe-Arg-Trp-NH Lead to Potent and Selective Agonists at hMC1R and hMC4R. Journal of Medicinal Chemistry. 66: 6715-6724
Tomassi S, Dimmito MP, Cai M, et al. (2022) CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists. Journal of Medicinal Chemistry
Mehr-Un-Nisa, Munawar MA, Rankin D, et al. (2021) C-terminal modified Enkephalin-like tetrapeptides with enhanced affinities at the kappa opioid receptor and monoamine transporters. Bioorganic & Medicinal Chemistry. 51: 116509
Zhou Y, Chawla MK, Rios-Monterrosa JL, et al. (2021) Aged Brains Express Less Melanocortin Receptors, Which Correlates with Age-Related Decline of Cognitive Functions. Molecules (Basel, Switzerland). 26
Keresztes A, Olson K, Nguyen P, et al. (2021) Antagonism of the Mu-Delta Opioid Receptor Heterodimer Enhances Opioid Anti-Nociception by Activating Src and CaMKII Signaling. Pain
Lee YS, Remesic M, Ramos-Colon C, et al. (2021) Multifunctional Enkephalin Analogs with a New Biological Profile: MOR/DOR Agonism and KOR Antagonism. Biomedicines. 9
Kondrashov M, Svensson SPS, Ström P, et al. (2021) Multiple Applications of a Novel Biarsenical Imaging Probe in Fluorescence and PET Imaging of Melanoma. Bioconjugate Chemistry
Zhou Y, Mowlazadeh Haghighi S, Liu Z, et al. (2020) Development of Ligand-Drug Conjugates Targeting Melanoma through the Overexpressed Melanocortin 1 Receptor. Acs Pharmacology & Translational Science. 3: 921-930
Kadiri JJ, Thapa K, Kaipio K, et al. (2020) Melanocortin 3 receptor activation with [D-Trp8]-γ-MSH suppresses inflammation in apolipoprotein E deficient mice. European Journal of Pharmacology. 173186
Gao F, Handl H, Vagner J, et al. (2020) Convenient and Efficient Synthesis of a Lanthanide-Coordinated, Diethylene Triamine Pentaacetic Acid Labeled Biopolymer as an Assay for the Cholecystokinin B Receptor. Journal of Applied Polymer Science. Applied Polymer Symposium. 106: 2683-2688
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