Shu He, Ph.D.

Affiliations: 
2000 Wichita State University, Wichita, KS, United States 
Area:
Biochemistry, Pharmaceutical Chemistry
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"Shu He"
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William C. Groutas grad student 2000 Wichita State University
 (Heterocyclic inhibitors of human leukocyte elastase, proteinase 3, cathepsin G and chymase.)
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Publications

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Groutas WC, He S, Kuang R, et al. (2001) Inhibition of serine proteases by functionalized sulfonamides coupled to the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold. Bioorganic & Medicinal Chemistry. 9: 1543-8
Groutas WC, Epp JB, Kuang R, et al. (2001) 1,2,5-Thiadiazolidin-3-one 1,1 dioxide: a powerful scaffold for probing the S' subsites of (chymo)trypsin-like serine proteases. Archives of Biochemistry and Biophysics. 385: 162-9
He S, Yu H, Fu Q, et al. (2001) A one-step protocol for the N-chloromethylation of heterocyclic imides Synthetic Communications. 31: 3055-3058
He S, Kuang R, Venkataraman R, et al. (2000) Potent inhibition of serine proteases by heterocyclic sulfide derivatives of 1,2,5-thiadiazolidin-3-one 1,1 dioxide. Bioorganic & Medicinal Chemistry. 8: 1713-7
Kuang R, Epp JB, Ruan S, et al. (2000) Utilization of the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold in the design of potent inhibitors of serine proteases: SAR studies using carboxylates. Bioorganic & Medicinal Chemistry. 8: 1005-16
Groutas WC, Schechter NM, He S, et al. (1999) Human chymase inhibitors based on the 1,2,5-thiadiazolidin-3-one 1,1 dioxide scaffold. Bioorganic & Medicinal Chemistry Letters. 9: 2199-204
Kuang R, Epp JB, Ruan S, et al. (1999) A General Inhibitor Scaffold for Serine Proteases with a (Chymo)trypsin-Like Fold:  Solution-Phase Construction and Evaluation of the First Series of Libraries of Mechanism-Based Inhibitors Journal of the American Chemical Society. 121: 8128-8129
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