Timothy J. Mitchison
Affiliations: | Systems Biology | Harvard Medical School, Boston, MA, United States |
Area:
Microtubules, Actin, Mitosis, Cell cycleWebsite:
http://www.hms.harvard.edu/dms/bbs/fac/Mitchison.phpGoogle:
"Timothy J. Mitchison"Bio:
http://mitchison.med.harvard.edu/Tim_page.html
https://sysbio.med.harvard.edu/facultys/timothy-j-mitchison-phd
http://www.fas.harvard.edu/~biophys/Timothy_J_Mitchison.htm
Discovered microtubule dynamic instability.
Tim Mitchison obtained a biochemistry degree at Oxford University, UK, and then moved to the laboratory of Marc Kirschner for his Ph.D. thesis, during which he purified tubulin from centrosomes and characterized the ‘dynamic instability’ that underlies microtubule growth. He started his own group at the University of California, San Francisco (UCSF), USA, in 1988 and 9 years later moved to the systems biology department at Harvard Medical School, Boston, Massachusetts, USA. He became the President of the American Society for Cell Biology in 2010.
Mean distance: (not calculated yet)
Cross-listing: Cell Biology Tree
Parents
Sign in to add mentor| Marc W. Kirschner | grad student | 1984 | UCSF | |
| (Structure and dynamics of organized microtubule arrays) | ||||
Children
Sign in to add trainee| Thomas U . | grad student | Harvard Medical School (Cell Biology Tree) | |
| Matt Welch | grad student | UCSF (Cell Biology Tree) | |
| Julie Theriot | grad student | 1993 | UCSF |
| Narat J. Eungdamrong | grad student | 2002 | Harvard (Cell Biology Tree) |
| Michele Shirasu-Hiza | grad student | 2003 | UCSF (Cell Biology Tree) |
| Zoltan Maliga | grad student | 2004 | Harvard (Cell Biology Tree) |
| David T. Miyamoto | grad student | 2004 | Harvard (Cell Biology Tree) |
| Justin C. Yarrow | grad student | 2004 | Harvard (Cell Biology Tree) |
| Zachary E. Perlman | grad student | 2005 | Harvard (Cell Biology Tree) |
| Alina M. Vrabioiu | grad student | 2006 | Harvard (Cell Biology Tree) |
| Aaron C. Groen | grad student | 2008 | Harvard (Cell Biology Tree) |
| Hao Y. Kueh | grad student | 2008 | Harvard (Cell Biology Tree) |
| Hsiao-Chun Huang | grad student | 2010 | Harvard (Cell Biology Tree) |
| Martin Wühr | grad student | 2005-2010 | Harvard (Cell Biology Tree) |
| Chi-Kuo Hu | grad student | 2011 | Harvard (Cell Biology Tree) |
| Nefeli E. Georgoulia | grad student | 2014 | Harvard (Cell Biology Tree) |
| Arshad Desai | post-doc | UCSF (Cell Biology Tree) | |
| Tarun Kapoor | post-doc | Harvard Medical School | |
| Thomas U. Mayer | post-doc | (Cell Biology Tree) | |
| Yuyu Song | post-doc | Harvard (Neurotree) | |
| Jack Taunton | post-doc | Harvard Medical School | |
| Yixian Zheng | post-doc | UCSF (Cell Biology Tree) | |
| Ivana Gasic | post-doc | 2016- | Harvard Medical School (Cell Biology Tree) |
| Xiang Deng | post-doc | 2017- | Harvard Medical School (Cell Biology Tree) |
| Tae Yeon Yoo | post-doc | 2018- | Harvard Medical School (Cell Biology Tree) |
| Anthony Hyman | post-doc | 1993 | UCSF |
| Tatsuya Hirano | post-doc | 1989-1995 | UCSF (Cell Biology Tree) |
| Claire Ellen Walczak | post-doc | 1998 | UCSF |
| R. Scott Lokey | post-doc | 2002 | Harvard Medical School |
| Aaron F. Straight | post-doc | 2004 | Harvard Medical School |
| Ulrike S. Eggert | post-doc | 2001-2006 | Harvard Medical School |
| Paul Chang | post-doc | 2007 | Harvard Medical School |
| Daniel J. Needleman | post-doc | 2005-2008 | Harvard |
| Ethan C. Garner | post-doc | 2012 | Harvard Medical School |
| James D. Orth | post-doc | 2005-2012 | (Neurotree) |
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Publications
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| Deng X, Bradshaw G, Kalocsay M, et al. (2025) Tubulin Regulates the Stability and Localization of STMN2 by Binding Preferentially to Its Soluble Form. Biorxiv : the Preprint Server For Biology |
| Chen A, Lupan AM, Quek RT, et al. (2024) A coronaviral pore-replicase complex links RNA synthesis and export from double-membrane vesicles. Science Advances. 10: eadq9580 |
| Fang R, Bai L, Li B, et al. (2024) Episodic Transport of Protein Aggregates Achieves a Positive Size Selectivity in Aggresome Formation. Biorxiv : the Preprint Server For Biology |
| Deng X, Seguinot BO, Bradshaw G, et al. (2024) STMND1 is A Phylogenetically Ancient Stathmin which Localizes to Motile Cilia and Exhibits Nuclear Translocation that Is Inhibited When Soluble Tubulin Concentration Increases. Molecular Biology of the Cell. mbcE23120514 |
| Yoo TY, Mitchison TJ. (2024) Quantitative comparison of nuclear transport inhibition by SARS coronavirus ORF6 reveals the importance of oligomerization. Proceedings of the National Academy of Sciences of the United States of America. 121: e2307997121 |
| Quek RT, Hardy KS, Walker SG, et al. (2023) Screen for Modulation of Nucleocapsid Protein Condensation Identifies Small Molecules with Anti-Coronavirus Activity. Acs Chemical Biology |
| Van Itallie ES, Field CM, Mitchison TJ, et al. (2022) Dorsal lip maturation and initial archenteron extension depend on Wnt11 family ligands. Developmental Biology. 493: 67-79 |
| Ng TL, Olson EJ, Yoo TY, et al. (2022) High-Content Screening and Computational Prediction Reveal Viral Genes That Suppress the Innate Immune Response. Msystems. e0146621 |
| Yoo TY, Mitchison T. (2021) Quantification of nuclear transport inhibition by SARS-CoV-2 ORF6 using a broadly applicable live-cell dose-response pipeline. Biorxiv : the Preprint Server For Biology |
| Mitchison TJ, Field CM. (2021) Self-Organization of Cellular Units. Annual Review of Cell and Developmental Biology |