Timothy J. Mitchison

Affiliations: 
Systems Biology Harvard Medical School, Boston, MA, United States 
Area:
Microtubules, Actin, Mitosis, Cell cycle
Website:
http://www.hms.harvard.edu/dms/bbs/fac/Mitchison.php
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"Timothy J. Mitchison"
Bio:

http://mitchison.med.harvard.edu/Tim_page.html
https://sysbio.med.harvard.edu/facultys/timothy-j-mitchison-phd
http://www.fas.harvard.edu/~biophys/Timothy_J_Mitchison.htm
Discovered microtubule dynamic instability.
Tim Mitchison obtained a biochemistry degree at Oxford University, UK, and then moved to the laboratory of Marc Kirschner for his Ph.D. thesis, during which he purified tubulin from centrosomes and characterized the ‘dynamic instability’ that underlies microtubule growth. He started his own group at the University of California, San Francisco (UCSF), USA, in 1988 and 9 years later moved to the systems biology department at Harvard Medical School, Boston, Massachusetts, USA. He became the President of the American Society for Cell Biology in 2010.

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Cross-listing: Cell Biology Tree

Parents

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Marc W. Kirschner grad student 1984 UCSF
 (Structure and dynamics of organized microtubule arrays)

Children

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Thomas U . grad student Harvard Medical School (Cell Biology Tree)
Matt Welch grad student UCSF (Cell Biology Tree)
Julie Theriot grad student 1993 UCSF
Narat J. Eungdamrong grad student 2002 Harvard (Cell Biology Tree)
Michele Shirasu-Hiza grad student 2003 UCSF (Cell Biology Tree)
Zoltan Maliga grad student 2004 Harvard (Cell Biology Tree)
David T. Miyamoto grad student 2004 Harvard (Cell Biology Tree)
Justin C. Yarrow grad student 2004 Harvard (Cell Biology Tree)
Zachary E. Perlman grad student 2005 Harvard (Cell Biology Tree)
Alina M. Vrabioiu grad student 2006 Harvard (Cell Biology Tree)
Aaron C. Groen grad student 2008 Harvard (Cell Biology Tree)
Hao Y. Kueh grad student 2008 Harvard (Cell Biology Tree)
Hsiao-Chun Huang grad student 2010 Harvard (Cell Biology Tree)
Martin Wühr grad student 2005-2010 Harvard (Cell Biology Tree)
Chi-Kuo Hu grad student 2011 Harvard (Cell Biology Tree)
Nefeli E. Georgoulia grad student 2014 Harvard (Cell Biology Tree)
Arshad Desai post-doc UCSF (Cell Biology Tree)
Tarun Kapoor post-doc Harvard Medical School
Thomas U. Mayer post-doc (Cell Biology Tree)
Yuyu Song post-doc Harvard (Neurotree)
Jack Taunton post-doc Harvard Medical School
Yixian Zheng post-doc UCSF (Cell Biology Tree)
Ivana Gasic post-doc 2016- Harvard Medical School (Cell Biology Tree)
Xiang Deng post-doc 2017- Harvard Medical School (Cell Biology Tree)
Tae Yeon Yoo post-doc 2018- Harvard Medical School (Cell Biology Tree)
Anthony Hyman post-doc 1993 UCSF
Tatsuya Hirano post-doc 1989-1995 UCSF (Cell Biology Tree)
Claire Ellen Walczak post-doc 1998 UCSF
R. Scott Lokey post-doc 2002 Harvard Medical School
Aaron F. Straight post-doc 2004 Harvard Medical School
Ulrike S. Eggert post-doc 2001-2006 Harvard Medical School
Paul Chang post-doc 2007 Harvard Medical School
Daniel J. Needleman post-doc 2005-2008 Harvard
Ethan C. Garner post-doc 2012 Harvard Medical School
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Publications

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Ng TL, Olson EJ, Yoo TY, et al. (2022) High-Content Screening and Computational Prediction Reveal Viral Genes That Suppress the Innate Immune Response. Msystems. e0146621
Yoo TY, Mitchison T. (2021) Quantification of nuclear transport inhibition by SARS-CoV-2 ORF6 using a broadly applicable live-cell dose-response pipeline. Biorxiv : the Preprint Server For Biology
Mitchison TJ, Field CM. (2021) Self-Organization of Cellular Units. Annual Review of Cell and Developmental Biology
Yoo TY, Mitchison TJ. (2021) O-GlcNAc modification of nuclear pore complexes accelerates bidirectional transport. The Journal of Cell Biology. 220
Pelletier JF, Field CM, Fuerthauer S, et al. (2020) Co-movement of astral microtubules, organelles and F-actin by dynein and actomyosin forces in frog egg cytoplasm. Elife. 9
Luthria G, Li R, Wang S, et al. (2020) In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells. Nature Communications. 11: 3521
Geisterfer ZM, Zhu DY, Mitchison TJ, et al. (2020) Microtubule Growth Rates Are Sensitive to Global and Local Changes in Microtubule Plus-End Density. Current Biology : Cb
Gasic I, Groendyke BJ, Nowak RP, et al. (2020) Tubulin Resists Degradation by Cereblon-Recruiting PROTACs. Cells. 9
Lin Z, Gasic I, Chandrasekaran V, et al. (2019) TTC5 mediates autoregulation of tubulin via mRNA degradation. Science (New York, N.Y.)
Mitchison TJ, Field CM. (2019) Toward synthetic cells. Science (New York, N.Y.). 366: 569-570
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