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Arun K. Ghosh

Affiliations:

Purdue University, West Lafayette, IN, United States

Area:

HIV-1 protease inhibitors

Website:

http://www.chem.purdue.edu/ghosh/

Google:

Bio:

http://media.iupac.org/news/archives/2010/IUPAC_Richter_Prize_2010.pdf

Mean distance: 7.29

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Parents

Alan P. Kozikowski	grad student	1985	University of Pittsburgh
(Stereoselection in nitrile oxide cycloaddition, metalation-alkylation of isoxazlines and their application to the synthesis of 2-deoxy-D-ribose, (+)-Blastmycinone, and (+)-Prelog-Djerassi lactone. Part II, Pyranoannulation and an enantioselective ...)
Elias James Corey	post-doc	1985-1988	Harvard

Children

Xiaoming Xu	grad student	2008	Purdue
Sarang S. Kulkarni	grad student	2009	Purdue
Kai Xi	grad student	2009	Purdue
Sofiya Yashchuk	grad student	2010	Purdue
Hao Yuan	grad student	2011	Purdue
Zachary L. Dawson	grad student	2012	Purdue
Jorden P. Kass	grad student	2012	Purdue
Khriesto A. Shurrush	grad student	2013	Purdue
Chad A. Keyes	grad student	2014	Purdue
Prasanth Reddy Nyalapatla	grad student	2012-2017	Purdue
Heather L Osswald	grad student	2012-2017	Purdue
Miranda Belcher	grad student	2016-2020	Purdue
Satish Kovela	post-doc		Purdue
Perali Ramu Sridhar	post-doc	2004-2006	Purdue
Gangarajula Sudhakar	post-doc	2007-2008	Purdue
Koena Ghosh	post-doc	2009-2011	Purdue

Collaborators

BETA: Related publications

Publications

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Ghosh AK, Yadav M, Sharma A, et al. (2025) Potent HIV‑1 protease inhibitors containing oxabicyclo octanol-derived P2-ligands: Design, synthesis, and X‑ray structural studies of inhibitor-HIV-1 protease complexes. Bioorganic & Medicinal Chemistry Letters. 130109
Ghosh AK, Gulliver JP. (2024) Total Syntheses of Strasseriolide A and Strasseriolide B, Potent Antimalarial Agents. The Journal of Organic Chemistry
Ghosh AK, Lee D, Sharma A, et al. (2024) Design of substituted tetrahydrofuran derivatives for HIV-1 protease inhibitors: synthesis, biological evaluation, and X-ray structural studies. Organic & Biomolecular Chemistry
Ghosh AK, Sharma A, Ghazi S. (2024) An Enzymatic Route to the Synthesis of Tricyclic Fused Hexahydrofuranofuran P2-Ligand for a Series of Highly Potent HIV-1 Protease Inhibitors. Tetrahedron Letters. 140
Ghosh AK, Yadav M, Iddum S, et al. (2024) Exploration of P1 and P4 modifications of nirmatrelvir: Design, synthesis, biological evaluation, and X-ray structural studies of SARS-CoV-2 Mpro inhibitors. European Journal of Medicinal Chemistry. 267: 116132
Ghosh AK, Yadav M. (2023) Synthesis of optically active SARS-CoV-2 Mpro inhibitor drug nirmatrelvir (Paxlovid): an approved treatment of COVID-19. Organic & Biomolecular Chemistry. 21: 5768-5774
Ghosh AK, Harper M, Robinson WL. (2023) Total Synthesis of Neuroprotective Agents, (+)-Lycibarbarine A and (-)-Lycibarbarine B. The Journal of Organic Chemistry
Ghosh AK, Mishevich JL, Kovela S, et al. (2023) Exploration of imatinib and nilotinib-derived templates as the P2-Ligand for HIV-1 protease inhibitors: Design, synthesis, protein X-ray structural studies, and biological evaluation. European Journal of Medicinal Chemistry. 255: 115385
Ghosh AK, Shahabi D, Kipfmiller M, et al. (2023) Evaluation of Darunavir-derived HIV-1 protease inhibitors incorporating P2' amide-derivatives: Synthesis, biological evaluation and structural studies. Bioorganic & Medicinal Chemistry Letters. 129168
Ghosh AK, Yuan H. (2022) Total Syntheses of the Proposed Structure of Iriomoteolide-1a, -1b and Synthesis of Three Derivatives for Structural Studies. Marine Drugs. 20

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