Arun K. Ghosh

Affiliations: 
Purdue University, West Lafayette, IN, United States 
Area:
HIV-1 protease inhibitors
Website:
http://www.chem.purdue.edu/ghosh/
Google:
"Arun Ghosh"
Bio:

http://media.iupac.org/news/archives/2010/IUPAC_Richter_Prize_2010.pdf

Mean distance: 7.29
 

Parents

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Alan P. Kozikowski grad student 1985 University of Pittsburgh
 (Stereoselection in nitrile oxide cycloaddition, metalation-alkylation of isoxazlines and their application to the synthesis of 2-deoxy-D-ribose, (+)-Blastmycinone, and (+)-Prelog-Djerassi lactone. Part II, Pyranoannulation and an enantioselective ...)
Elias James Corey post-doc 1985-1988 Harvard

Children

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Xiaoming Xu grad student 2008 Purdue
Sarang S. Kulkarni grad student 2009 Purdue
Kai Xi grad student 2009 Purdue
Sofiya Yashchuk grad student 2010 Purdue
Hao Yuan grad student 2011 Purdue
Zachary L. Dawson grad student 2012 Purdue
Jorden P. Kass grad student 2012 Purdue
Khriesto A. Shurrush grad student 2013 Purdue
Chad A. Keyes grad student 2014 Purdue
Prasanth Reddy Nyalapatla grad student 2012-2017 Purdue
Heather L Osswald grad student 2012-2017 Purdue
Miranda Belcher grad student 2016-2020 Purdue
Satish Kovela post-doc Purdue
Perali Ramu Sridhar post-doc 2004-2006 Purdue
Gangarajula Sudhakar post-doc 2007-2008 Purdue
Koena Ghosh post-doc 2009-2011 Purdue
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Publications

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Ghosh AK, Yadav M, Sharma A, et al. (2025) Potent HIV‑1 protease inhibitors containing oxabicyclo octanol-derived P2-ligands: Design, synthesis, and X‑ray structural studies of inhibitor-HIV-1 protease complexes. Bioorganic & Medicinal Chemistry Letters. 130109
Ghosh AK, Gulliver JP. (2024) Total Syntheses of Strasseriolide A and Strasseriolide B, Potent Antimalarial Agents. The Journal of Organic Chemistry
Ghosh AK, Lee D, Sharma A, et al. (2024) Design of substituted tetrahydrofuran derivatives for HIV-1 protease inhibitors: synthesis, biological evaluation, and X-ray structural studies. Organic & Biomolecular Chemistry
Ghosh AK, Sharma A, Ghazi S. (2024) An Enzymatic Route to the Synthesis of Tricyclic Fused Hexahydrofuranofuran P2-Ligand for a Series of Highly Potent HIV-1 Protease Inhibitors. Tetrahedron Letters. 140
Ghosh AK, Yadav M, Iddum S, et al. (2024) Exploration of P1 and P4 modifications of nirmatrelvir: Design, synthesis, biological evaluation, and X-ray structural studies of SARS-CoV-2 Mpro inhibitors. European Journal of Medicinal Chemistry. 267: 116132
Ghosh AK, Yadav M. (2023) Synthesis of optically active SARS-CoV-2 Mpro inhibitor drug nirmatrelvir (Paxlovid): an approved treatment of COVID-19. Organic & Biomolecular Chemistry. 21: 5768-5774
Ghosh AK, Harper M, Robinson WL. (2023) Total Synthesis of Neuroprotective Agents, (+)-Lycibarbarine A and (-)-Lycibarbarine B. The Journal of Organic Chemistry
Ghosh AK, Mishevich JL, Kovela S, et al. (2023) Exploration of imatinib and nilotinib-derived templates as the P2-Ligand for HIV-1 protease inhibitors: Design, synthesis, protein X-ray structural studies, and biological evaluation. European Journal of Medicinal Chemistry. 255: 115385
Ghosh AK, Shahabi D, Kipfmiller M, et al. (2023) Evaluation of Darunavir-derived HIV-1 protease inhibitors incorporating P2' amide-derivatives: Synthesis, biological evaluation and structural studies. Bioorganic & Medicinal Chemistry Letters. 129168
Ghosh AK, Yuan H. (2022) Total Syntheses of the Proposed Structure of Iriomoteolide-1a, -1b and Synthesis of Three Derivatives for Structural Studies. Marine Drugs. 20
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