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Arun K. Ghosh

Affiliations: 
Purdue University, West Lafayette, IN, United States 
Area:
HIV-1 protease inhibitors
Website:
http://www.chem.purdue.edu/ghosh/
Google:
"Arun Ghosh"
Bio:

http://media.iupac.org/news/archives/2010/IUPAC_Richter_Prize_2010.pdf

Mean distance: 7.29
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Parents

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Alan P. Kozikowski grad student 1985 University of Pittsburgh
 (Stereoselection in nitrile oxide cycloaddition, metalation-alkylation of isoxazlines and their application to the synthesis of 2-deoxy-D-ribose, (+)-Blastmycinone, and (+)-Prelog-Djerassi lactone. Part II, Pyranoannulation and an enantioselective ...)
Elias James Corey post-doc 1985-1988 Harvard

Children

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Xiaoming Xu grad student 2008 Purdue
Sarang S. Kulkarni grad student 2009 Purdue
Kai Xi grad student 2009 Purdue
Sofiya Yashchuk grad student 2010 Purdue
Hao Yuan grad student 2011 Purdue
Zachary L. Dawson grad student 2012 Purdue
Jorden P. Kass grad student 2012 Purdue
Khriesto A. Shurrush grad student 2013 Purdue
Chad A. Keyes grad student 2014 Purdue
Prasanth Reddy Nyalapatla grad student 2012-2017 Purdue
Heather L Osswald grad student 2012-2017 Purdue
Miranda Belcher grad student 2016-2020 Purdue
Satish Kovela post-doc Purdue
Perali Ramu Sridhar post-doc 2004-2006 Purdue
Gangarajula Sudhakar post-doc 2007-2008 Purdue
Koena Ghosh post-doc 2009-2011 Purdue

Collaborators

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Publications

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Ghosh AK, Yadav M, Iddum S, et al. (2024) Exploration of P1 and P4 modifications of nirmatrelvir: Design, synthesis, biological evaluation, and X-ray structural studies of SARS-CoV-2 Mpro inhibitors. European Journal of Medicinal Chemistry. 267: 116132
Ghosh AK, Yadav M. (2023) Synthesis of optically active SARS-CoV-2 Mpro inhibitor drug nirmatrelvir (Paxlovid): an approved treatment of COVID-19. Organic & Biomolecular Chemistry. 21: 5768-5774
Ghosh AK, Harper M, Robinson WL. (2023) Total Synthesis of Neuroprotective Agents, (+)-Lycibarbarine A and (-)-Lycibarbarine B. The Journal of Organic Chemistry
Ghosh AK, Mishevich JL, Kovela S, et al. (2023) Exploration of imatinib and nilotinib-derived templates as the P2-Ligand for HIV-1 protease inhibitors: Design, synthesis, protein X-ray structural studies, and biological evaluation. European Journal of Medicinal Chemistry. 255: 115385
Ghosh AK, Shahabi D, Kipfmiller M, et al. (2023) Evaluation of Darunavir-derived HIV-1 protease inhibitors incorporating P2' amide-derivatives: Synthesis, biological evaluation and structural studies. Bioorganic & Medicinal Chemistry Letters. 129168
Ghosh AK, Yuan H. (2022) Total Syntheses of the Proposed Structure of Iriomoteolide-1a, -1b and Synthesis of Three Derivatives for Structural Studies. Marine Drugs. 20
Ghosh AK, Weber IT, Mitsuya H. (2022) Beyond darunavir: recent development of next generation HIV-1 protease inhibitors to combat drug resistance. Chemical Communications (Cambridge, England)
Ghosh AK, Kovela S, Sharma A, et al. (2022) Design, Synthesis and X-ray Structural Studies of Potent HIV-1 Protease Inhibitors Containing C-4 Substituted Tricyclic Hexahydro-furofuran derivatives as P2 ligands. Chemmedchem
Amano M, Yedidi RS, Salcedo-Gómez PM, et al. (2022) Fluorine-Modifications Contribute to Potent Antiviral Activity against Highly Drug-Resistant HIV-1 and Favorable Blood-Brain Barrier (BBB) Penetration Property of Novel Central Nervous System (CNS)-targeting HIV-1 Protease Inhibitors . Antimicrobial Agents and Chemotherapy. AAC0171521
Ghosh AK, Shahabi D, Yadav M, et al. (2021) Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors. Molecules (Basel, Switzerland). 26
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