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Arun K. Ghosh

Affiliations:

Purdue University, West Lafayette, IN, United States

Area:

HIV-1 protease inhibitors

Website:

http://www.chem.purdue.edu/ghosh/

Google:

Bio:

http://media.iupac.org/news/archives/2010/IUPAC_Richter_Prize_2010.pdf

Mean distance: 7.29

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Parents

Alan P. Kozikowski	grad student	1985	University of Pittsburgh
(Stereoselection in nitrile oxide cycloaddition, metalation-alkylation of isoxazlines and their application to the synthesis of 2-deoxy-D-ribose, (+)-Blastmycinone, and (+)-Prelog-Djerassi lactone. Part II, Pyranoannulation and an enantioselective ...)
Elias James Corey	post-doc	1985-1988	Harvard

Children

Xiaoming Xu	grad student	2008	Purdue
Sarang S. Kulkarni	grad student	2009	Purdue
Kai Xi	grad student	2009	Purdue
Sofiya Yashchuk	grad student	2010	Purdue
Hao Yuan	grad student	2011	Purdue
Zachary L. Dawson	grad student	2012	Purdue
Jorden P. Kass	grad student	2012	Purdue
Khriesto A. Shurrush	grad student	2013	Purdue
Chad A. Keyes	grad student	2014	Purdue
Prasanth Reddy Nyalapatla	grad student	2012-2017	Purdue
Heather L Osswald	grad student	2012-2017	Purdue
Perali Ramu Sridhar	post-doc	2004-2006	Purdue
Gangarajula Sudhakar	post-doc	2007-2008	Purdue
Koena Ghosh	post-doc	2009-2011	Purdue

Collaborators

BETA: Related publications

Publications

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Ghosh AK, Raghavaiah J, Shahabi D, et al. (2021) Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure-Activity Relationship, and X-ray Structural Studies. Journal of Medicinal Chemistry
Agniswamy J, Kneller DW, Ghosh AK, et al. (2021) Novel HIV PR inhibitors with C4-substituted bis-THF and bis-fluoro-benzyl target the two active site mutations of highly drug resistant mutant PR. Biochemical and Biophysical Research Communications. 566: 30-35
Ghosh AK, Yadav M. (2021) Highly Diastereoselective Intramolecular Asymmetric Oxidopyrylium-olefin [5 + 2] Cycloaddition and Synthesis of 8-Oxabicyclo[3.2.1]oct-3-enone Containing Ring Systems. The Journal of Organic Chemistry
Ghosh AK, Mishevich JL, Jurica MS. (2021) Spliceostatins and Derivatives: Chemical Syntheses and Biological Properties of Potent Splicing Inhibitors. Journal of Natural Products
Ghosh AK, Hsu CS. (2021) Enantioselective Total Synthesis of (+)-EBC-23, a Potent Anticancer Agent from the Australian Rainforest. The Journal of Organic Chemistry
Gamboa Lopez A, Allu SR, Mendez P, et al. (2021) Herboxidiene Features That Mediate Conformation-Dependent SF3B1 Interactions to Inhibit Splicing. Acs Chemical Biology
Yen YC, Kammeyer AM, Tirlangi J, et al. (2021) A Structure-Based Discovery Platform for BACE2 and the Development of Selective BACE Inhibitors. Acs Chemical Neuroscience
Hattori SI, Higashi-Kuwata N, Hayashi H, et al. (2021) A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication. Nature Communications. 12: 668
Ghosh AK, Allu SR, Reddy GC, et al. (2021) Design and synthesis of herboxidiene derivatives that potently inhibit splicing. Organic & Biomolecular Chemistry
Ghosh AK, Shahabi D. (2021) Synthesis of amide derivatives for electron deficient amines and functionalized carboxylic acids using EDC and DMAP and a catalytic amount of HOBt as the coupling reagents. Tetrahedron Letters. 63

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