Ron A. Laskey

University of Cambridge, Hutchison/MRC Research Centre 
Nuclear transport, mammalian DNA replication
"Ron Laskey"

Discovered nuclear localization signals, coined the phrase "molecular chaperone", with Dirk Gorlich discovered importins.

Mean distance: 11.16
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Wickramasinghe VO, Andrews R, Ellis P, et al. (2014) Selective nuclear export of specific classes of mRNA from mammalian nuclei is promoted by GANP. Nucleic Acids Research. 42: 5059-71
Poole E, Bain M, Teague L, et al. (2012) The Cellular Protein MCM3AP Is Required for Inhibition of Cellular DNA Synthesis by the IE86 Protein of Human Cytomegalovirus Plos One. 7
Wickramasinghe VO, McMurtrie PI, Mills AD, et al. (2010) mRNA export from mammalian cell nuclei is dependent on GANP. Current Biology : Cb. 20: 25-31
Laskey R. (2005) Solving mysteries of DNA replication and frog cloning Cell. 123: 760-762
Tachibana KK, Gonzalez MA, Guarguaglini G, et al. (2005) Depletion of licensing inhibitor geminin causes centrosome overduplication and mitotic defects Embo Reports. 6: 1052-1057
Laskey R. (2005) The Croonian Lecture 2001 hunting the antisocial cancer cell: MCM proteins and their exploitation Philosophical Transactions of the Royal Society B: Biological Sciences. 360: 1119-1132
McGeoch AT, Trakselis MA, Laskey RA, et al. (2005) Organization of the archaeal MCM complex on DNA and implications for the helicase mechanism Nature Structural and Molecular Biology. 12: 756-762
Gonzalez MA, Tachibana KEK, Laskey RA, et al. (2005) Control of DNA replication and its potential clinical exploitation Nature Reviews Cancer. 5: 135-141
Laskey RA, Madine MA. (2003) A rotary pumping model for helicase function of MCM proteins at a distance from replication forks Embo Reports. 4: 26-30
Takei Y, Assenberg M, Tsujimoto G, et al. (2002) The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3 Journal of Biological Chemistry. 277: 43121-43125
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