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J. M. Brown, Ph.D.

Affiliations: 
2004 The University of North Carolina at Greensboro, Greensboro, NC, United States 
Area:
Nutrition, Biochemistry, Pathology
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Michael K. McIntosh grad student 2004 The University of North Carolina at Greensboro
 (Isomer-specific mechanisms by which conjugated linoleic acid opposes human adipogenesis.)

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Publications

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Kim Y, Gromovsky AD, Brown JM, et al. (2018) Gamma-tocotrienol attenuates the aberrant lipid mediator production in NLRP3 inflammasome-stimulated macrophages. The Journal of Nutritional Biochemistry. 58: 169-177
Zhao S, Mugabo Y, Ballentine G, et al. (2016) α/β-Hydrolase Domain 6 Deletion Induces Adipose Browning and Prevents Obesity and Type 2 Diabetes. Cell Reports
Schreiber R, Hofer P, Taschler U, et al. (2015) Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity. Proceedings of the National Academy of Sciences of the United States of America. 112: 13850-5
Shen W, Chuang CC, Martinez K, et al. (2013) Conjugated linoleic acid reduces adiposity and increases markers of browning and inflammation in white adipose tissue of mice. Journal of Lipid Research. 54: 909-22
Lord CC, Betters JL, Ivanova PT, et al. (2012) CGI-58/ABHD5-derived signaling lipids regulate systemic inflammation and insulin action. Diabetes. 61: 355-63
Brown JM, Chung S, Sawyer JK, et al. (2010) Combined therapy of dietary fish oil and stearoyl-CoA desaturase 1 inhibition prevents the metabolic syndrome and atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 24-30
Brown JM, Chung S, Sawyer JK, et al. (2008) Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosis. Circulation. 118: 1467-75
Brown JM, Chung S, Das A, et al. (2007) CGI-58 facilitates the mobilization of cytoplasmic triglyceride for lipoprotein secretion in hepatoma cells. Journal of Lipid Research. 48: 2295-305
Chung S, Brown JM, Provo JN, et al. (2005) Conjugated linoleic acid promotes human adipocyte insulin resistance through NFkappaB-dependent cytokine production. The Journal of Biological Chemistry. 280: 38445-56
Chung S, Brown JM, Sandberg MB, et al. (2005) Trans-10,cis-12 CLA increases adipocyte lipolysis and alters lipid droplet-associated proteins: role of mTOR and ERK signaling. Journal of Lipid Research. 46: 885-95
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