James Gaylor, Ph.D.

Affiliations: 
Chemistry Cornell University, Ithaca, NY, United States 
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"James Gaylor"
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Parents

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Carl A. Baumann grad student 1960 UW Madison
 (Biosynthesis of sterols as altered by carcinogens or nicotinic acid)

Children

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Wayne Bowen grad student 1975-1981 Cornell
Colin R. Jefcoate post-doc 1967-1969 Cornell
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Publications

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Gaylor JL. (2002) Membrane-bound enzymes of cholesterol synthesis from lanosterol. Biochemical and Biophysical Research Communications. 292: 1139-46
Gachotte D, Barbuch R, Gaylor J, et al. (1998) Characterization of the Saccharomyces cerevisiae ERG26 gene encoding the C-3 sterol dehydrogenase (C-4 decarboxylase) involved in sterol biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 95: 13794-9
Trzaskos JM, Fischer RT, Ko SS, et al. (1995) Substrate-based inhibitors of lanosterol 14 alpha-methyl demethylase: II. Time-dependent enzyme inactivation by selected oxylanosterol analogs. Biochemistry. 34: 9677-81
Trzaskos JM, Ko SS, Magolda RL, et al. (1995) Substrate-based inhibitors of lanosterol 14 alpha-methyl demethylase: I. Assessment of inhibitor structure-activity relationship and cholesterol biosynthesis inhibition properties. Biochemistry. 34: 9670-6
Kim CK, Jeon KI, Lim DM, et al. (1995) Cholesterol biosynthesis from lanosterol: regulation and purification of rat hepatic sterol 14-reductase. Biochimica Et Biophysica Acta. 1259: 39-48
Trzaskos JM, Magolda RL, Favata MF, et al. (1993) Modulation of 3-hydroxy-3-methylglutaryl-CoA reductase by 15 alpha-fluorolanost-7-en-3 beta-ol. A mechanism-based inhibitor of cholesterol biosynthesis. The Journal of Biological Chemistry. 268: 22591-9
Billheimer JT, Gaylor JL. (1990) Effect of lipid composition on the transfer of sterols mediated by non-specific lipid transfer protein (sterol carrier protein2). Biochimica Et Biophysica Acta. 1046: 136-43
Fischer RT, Stam SH, Johnson PR, et al. (1989) Mechanistic studies of lanosterol 14 alpha-methyl demethylase: substrate requirements for the component reactions catalyzed by a single cytochrome P-450 isozyme. Journal of Lipid Research. 30: 1621-32
Reinhart MP, Billheimer JT, Faust JR, et al. (1987) Subcellular localization of the enzymes of cholesterol biosynthesis and metabolism in rat liver. The Journal of Biological Chemistry. 262: 9649-55
Kawata S, Trzaskos JM, Gaylor JL. (1986) Affinity chromatography of microsomal enzymes on immobilized detergent-solubilized cytochrome b5. The Journal of Biological Chemistry. 261: 3790-9
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