Lindsay R. Comstock, Ph.D.

Affiliations: 
2005 University of Wisconsin, Madison, Madison, WI 
Area:
Pharmaceutical Chemistry, Organic Chemistry
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"Lindsay Comstock"
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Scott R. Rajski grad student 2005 UW Madison
 (Sequence-specific DNA strand scission: Evaluation of a methyltransferase-dependent chemoselective ligation.)
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Publications

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Hymbaugh S, Pecor L, Tracy CM, et al. (2018) PRMT1-dependent Labeling and Isolation of Histone H4 Through N-Mustard Analogs of S-Adenosyl-L-methionine. Chembiochem : a European Journal of Chemical Biology
Hymbaugh Bergman SJ, Comstock LR. (2015) N-mustard analogs of S-adenosyl-L-methionine as biochemical probes of protein arginine methylation. Bioorganic & Medicinal Chemistry. 23: 5050-5
Ramadan M, Bremner-Hay NK, Carlson SA, et al. (2014) Synthesis and evaluation of N6-substituted azide- and alkyne-bearing N-mustard analogs of S-adenosyl-l-methionine Tetrahedron. 70: 5291-5297
Du Y, Hendrick CE, Frye KS, et al. (2012) Fluorescent DNA labeling by N-mustard analogues of S-adenosyl-L-methionine. Chembiochem : a European Journal of Chemical Biology. 13: 2225-33
Mai V, Comstock LR. (2011) Synthesis of an azide-bearing N-mustard analogue of S-adenosyl-L-methionine. The Journal of Organic Chemistry. 76: 10319-24
Kasamatsu A, Nakao M, Smith BC, et al. (2011) Hydrolysis of O-acetyl-ADP-ribose isomers by ADP-ribosylhydrolase 3. The Journal of Biological Chemistry. 286: 21110-7
Comstock LR, Denu JM. (2007) Synthesis and biochemical evaluation of O-acetyl-ADP-ribose and N-acetyl analogs. Organic & Biomolecular Chemistry. 5: 3087-91
Comstock LR, Rajski SR. (2005) Methyltransferase-directed DNA strand scission. Journal of the American Chemical Society. 127: 14136-7
Comstock LR, Rajski SR. (2005) Conversion of DNA methyltransferases into azidonucleosidyl transferases via synthetic cofactors. Nucleic Acids Research. 33: 1644-52
Comstock LR, Rajski SR. (2004) Efficient synthesis of azide-bearing cofactor mimics. The Journal of Organic Chemistry. 69: 1425-8
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