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Gina M. Capiaux, Ph.D.

Affiliations: 
2002 Weill Cornell Medical College, New York, NY, United States 
Area:
Pharmacology
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"Gina Capiaux"
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Joseph R. Bertino grad student 2002 Weill Cornell Medical College
 (A fusion protein of mutant dihydrofolate reductase and mutant thymidylate synthase for conferring myeloprotection against methotrexate and 5-fluorouracil: Characterization and in vivo analysis.)

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Publications

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Capiaux GM, Budak-Alpdogan T, Alpdogan O, et al. (2004) Protection of hematopoietic stem cells from pemetrexed toxicity by retroviral gene transfer with a mutant dihydrofolate reductase-mutant thymidylate synthase fusion gene Cancer Gene Therapy. 11: 767-773
Capiaux GM, Budak-Alpdogan T, Takebe N, et al. (2003) Retroviral transduction of a mutant dihydrofolate reductase-thymidylate synthase fusion gene into murine marrow cells confers resistance to both methotrexate and 5-fluorouracil. Human Gene Therapy. 14: 435-46
Banerjee D, Mayer-Kuckuk P, Capiaux G, et al. (2002) Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase. Biochimica Et Biophysica Acta. 1587: 164-73
Sapse AM, Capiaux GM, Bertino JR. (2001) Examination of the reduced affinity of the thymidylate synthase G52S mutation for FdUMP by ab initio and semi-empirical studies. Molecular Medicine (Cambridge, Mass.). 7: 200-4
Banerjee D, Tong Y, Liu-Chen X, et al. (1999) Protection of bone marrow cells from toxicity of chemotherapeutic agents targeted toward thymidylate synthase by transfer of mutant forms of human thymidylate synthase cDNA. Progress in Experimental Tumor Research. 36: 107-14
Tong Y, Liu-Chen X, Ercikan-Abali EA, et al. (1998) Isolation and characterization of thymitaq (AG337) and 5-fluoro-2-deoxyuridylate-resistant mutants of human thymidylate synthase from ethyl methanesulfonate-exposed human sarcoma HT1080 cells. The Journal of Biological Chemistry. 273: 11611-8
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