Edward Elmer Knaus

Affiliations: 
1972-2008 Pharmacy University of Alberta, Edmonton, Alberta, Canada 
Area:
Pharmaceutical Chemistry, Pharmacology
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"Edward Elmer Knaus"
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Rudolph A. Abramovitch grad student 1971 University of Saskatchewan
 (Some studies of the chemistry of pyridine-1- oxides.)
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Publications

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Biggs JE, Stemkowski PL, Knaus EE, et al. (2015) Suppression of network activity in dorsal horn by gabapentin permeation of TRPV1 channels: implications for drug access to cytoplasmic targets. Neuroscience Letters. 584: 397-402
Xia Z, Knaus EE, Wiebe LI. (2013) Pharmacokinetics of 3'-O-retinoyl-5-fluoro-2'-deoxyuridine (RFUdR), a dual acting mutually masking prodrug, and its metabolites in tumor bearing mice. Current Drug Delivery. 10: 557-63
Bhardwaj A, Huang Z, Kaur J, et al. (2013) A diazen-1-ium-1,2-diolate analog of 7-azabenzobicyclo[2.2.1]heptane: synthesis, nitric oxide and nitroxyl release, in vitro hemodynamic, and anti-hypertensive studies. Bioorganic & Medicinal Chemistry Letters. 23: 2769-74
Huang Z, Kaur J, Bhardwaj A, et al. (2012) O2-sulfonylethyl protected isopropylamine diazen-1-ium-1,2-diolates as nitroxyl (HNO) donors: synthesis, β-elimination fragmentation, HNO release, positive inotropic properties, and blood pressure lowering studies. Journal of Medicinal Chemistry. 55: 10262-71
Bhardwaj A, Batchu SN, Kaur J, et al. (2012) Cardiovascular properties of a nitric oxide releasing rofecoxib analogue: beneficial anti-hypertensive activity and enhanced recovery in an ischemic reperfusion injury model. Chemmedchem. 7: 1365-8
Wiebe LI, Sun W, Zhou A, et al. (2012) Biochemistry and biology of 2'-Fluoro-2'-deoxythymidine (FT), a putative highly selective substrate for thymidine kinase type 2 (TK2). Current Radiopharmaceuticals. 5: 38-46
Abdur Rahim M, Praveen Rao PN, Bhardwaj A, et al. (2011) Isomeric acetoxy analogs of celecoxib and their evaluation as cyclooxygenase inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 6074-80
Abdellatif KR, Huang Z, Chowdhury MA, et al. (2011) A diazen-1-ium-1,2-diolated nitric oxide donor ester prodrug of 3-(4-hydroxymethylphenyl)-4-(4-methanesulfonylphenyl)-5H-furan-2-one: synthesis, biological evaluation and nitric oxide release studies. Bioorganic & Medicinal Chemistry Letters. 21: 3951-6
Huang Z, Velázquez CA, Abdellatif KR, et al. (2011) Ethanesulfohydroxamic acid ester prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs): synthesis, nitric oxide and nitroxyl release, cyclooxygenase inhibition, anti-inflammatory, and ulcerogenicity index studies. Journal of Medicinal Chemistry. 54: 1356-64
Huang Z, Velázquez C, Abdellatif K, et al. (2010) Acyclic triaryl olefins possessing a sulfohydroxamic acid pharmacophore: synthesis, nitric oxide/nitroxyl release, cyclooxygenase inhibition, and anti-inflammatory studies. Organic & Biomolecular Chemistry. 8: 4124-30
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