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Edward Elmer Knaus

Affiliations: 
1972-2008 Pharmacy University of Alberta, Edmonton, Alberta, Canada 
Area:
Pharmaceutical Chemistry, Pharmacology
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"Edward Elmer Knaus"
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Parents

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Rudolph A. Abramovitch grad student 1971 University of Saskatchewan
 (Some studies of the chemistry of pyridine-1- oxides.)

Children

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Keykavous Parang grad student 1997 University of Alberta
Praveen R. Perampalli Nekkar grad student 2004 University of Alberta
Mohsen Amini post-doc 1999-2000

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Publications

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Huang Z, Wu J, Zou Y, et al. (2018) Glutathione S-Transferase π-Activatable O2-(Sulfonylethyl Derived) Diazeniumdiolates Potently Suppress Melanoma In Vitro and In Vivo. Journal of Medicinal Chemistry
Zou Y, Yan C, Knaus EE, et al. (2017) Discovery of phosphorodiamidate mustard-based O2-phosphorylated diazeniumdiolates with potent anticancer activity Rsc Advances. 7: 18893-18899
Abdellatif KR, Moawad A, Knaus EE. (2014) Synthesis of new 1-(4-methane(amino)sulfonylphenyl)-5-(4-substituted-aminomethylphenyl)-3-trifluoromethyl-1H-pyrazoles: a search for novel nitric oxide donor anti-inflammatory agents. Bioorganic & Medicinal Chemistry Letters. 24: 5015-21
Bhardwaj A, Kaur J, Wuest F, et al. (2014) Fluorophore-labeled cyclooxygenase-2 inhibitors for the imaging of cyclooxygenase-2 overexpression in cancer: synthesis and biological studies. Chemmedchem. 9: 109-16, 240
Xia Z, Knaus EE, Wiebe LI. (2013) Pharmacokinetics of 3'-O-retinoyl-5-fluoro-2'-deoxyuridine (RFUdR), a dual acting mutually masking prodrug, and its metabolites in tumor bearing mice. Current Drug Delivery. 10: 557-63
Bhardwaj A, Huang Z, Kaur J, et al. (2013) A diazen-1-ium-1,2-diolate analog of 7-azabenzobicyclo[2.2.1]heptane: synthesis, nitric oxide and nitroxyl release, in vitro hemodynamic, and anti-hypertensive studies. Bioorganic & Medicinal Chemistry Letters. 23: 2769-74
Huang Z, Kaur J, Bhardwaj A, et al. (2012) O2-sulfonylethyl protected isopropylamine diazen-1-ium-1,2-diolates as nitroxyl (HNO) donors: synthesis, β-elimination fragmentation, HNO release, positive inotropic properties, and blood pressure lowering studies. Journal of Medicinal Chemistry. 55: 10262-71
Kaur J, Bhardwaj A, Huang Z, et al. (2012) N-1 and C-3 substituted indole Schiff bases as selective COX-2 inhibitors: synthesis and biological evaluation. Bioorganic & Medicinal Chemistry Letters. 22: 2154-9
Kaur J, Bhardwaj A, Huang Z, et al. (2012) Aspirin analogues as dual cyclooxygenase-2/5-lipoxygenase inhibitors: synthesis, nitric oxide release, molecular modeling, and biological evaluation as anti-inflammatory agents. Chemmedchem. 7: 144-50
Wiebe LI, Sun W, Zhou A, et al. (2012) Biochemistry and biology of 2'-Fluoro-2'-deoxythymidine (FT), a putative highly selective substrate for thymidine kinase type 2 (TK2). Current Radiopharmaceuticals. 5: 38-46
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