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J. David Castle, Ph.D.

Cell Biology University of Virginia, Charlottesville, VA 
Cell Biology, Membrane Trafficking, Cholesterol Regulation
"J. David Castle"

B.A. Carleton College 1968; Ph.D. in Cell Biology, Rockefeller University, 1974;
Postdoctoral with Wayne L. Hubbell, Biophysical Chemistry, Univ. California, Berkeley, 1975-78. Currently Professor of Cell Biology, University of Virginia School of Medicine.

Mean distance: 8.83


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George E. Palade grad student 1974 Rockefeller
 (Studies on the secretory process of the rabbit parotid)
Wayne Lester Hubbell post-doc 1975-1978 UC Berkeley


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Peter R. Arvan grad student 1984 Yale
Haini Liao grad student 2007 UVA
Quyen L. Aoh grad student 2009 UVA
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Kiessling V, Kreutzberger AJB, Liang B, et al. (2018) A molecular mechanism for calcium-mediated synaptotagmin-triggered exocytosis. Nature Structural & Molecular Biology. 25: 911-917
Harris MT, Hussain SS, Inouye CM, et al. (2018) Reinterpretation of the localization of the ATP binding cassette transporter ABCG1 in insulin-secreting cells and insights regarding its trafficking and function. Plos One. 13: e0198383
Hussain SS, Harris MT, Kreutzberger AJB, et al. (2018) Control of Insulin Granule Formation and Function by the ABC Transporters ABCG1 and ABCA1 and by Oxysterol Binding Protein OSBP. Molecular Biology of the Cell
Sturek JM, Castle JD, Trace AP, et al. (2010) An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic beta cells. The Journal of Clinical Investigation. 120: 2575-89
Aiyar SE, Park H, Aldo PB, et al. (2010) TMS, a chemically modified herbal derivative of resveratrol, induces cell death by targeting Bax. Breast Cancer Research and Treatment. 124: 265-77
Mota LJ, Ramsden AE, Liu M, et al. (2009) SCAMP3 is a component of the Salmonella-induced tubular network and reveals an interaction between bacterial effectors and post-Golgi trafficking. Cellular Microbiology. 11: 1236-53
Aoh QL, Castle AM, Hubbard CH, et al. (2009) SCAMP3 negatively regulates epidermal growth factor receptor degradation and promotes receptor recycling. Molecular Biology of the Cell. 20: 1816-32
Balasubramanian N, Scott DW, Castle JD, et al. (2007) Arf6 and microtubules in adhesion-dependent trafficking of lipid rafts. Nature Cell Biology. 9: 1381-91
Liao H, Keller SR, Castle JD. (2006) Insulin-regulated aminopeptidase marks an antigen-stimulated recycling compartment in mast cells. Traffic (Copenhagen, Denmark). 7: 155-67
White JM, Castle JD. (2005) Searching for the silver lining. Nature Structural & Molecular Biology. 12: 382-4
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