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Fengling Liu, Ph.D.

Affiliations: 
2007 Georgia State University, Atlanta, GA, United States 
Area:
Molecular Biology
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"Fengling Liu"
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Irene T. Weber grad student 2007 Georgia State
 (Kinetic and crystallographic studies of drug-resistant mutants of HIV -1 protease: Insights into the drug resistance mechanisms.)

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Liu F, Marquardt G, Kirschner AN, et al. (2010) Mapping the N-terminal residues of Epstein-Barr virus gp42 that bind gH/gL by using fluorescence polarization and cell-based fusion assays Journal of Virology. 84: 10375-10385
Liu F, Kovalevsky AY, Tie Y, et al. (2008) Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir. Journal of Molecular Biology. 381: 102-15
Sayer JM, Liu F, Ishima R, et al. (2008) Effect of the active site D25N mutation on the structure, stability, and ligand binding of the mature HIV-1 protease. The Journal of Biological Chemistry. 283: 13459-70
Kovalevsky AY, Chumanevich AA, Liu F, et al. (2007) Caught in the Act: the 1.5 A resolution crystal structures of the HIV-1 protease and the I54V mutant reveal a tetrahedral reaction intermediate. Biochemistry. 46: 14854-64
Kovalevsky AY, Liu F, Leshchenko S, et al. (2007) Corrigendum to "Ultra-high Resolution Crystal Structure of HIV-1 Protease Mutant Reveals Two Binding Sites for Clinical Inhibitor TMC114" [J. Mol. Biol. 363 (2006) 161-173] (DOI:10.1016/j.jmb.2006.08.007) Journal of Molecular Biology. 365: 901
Kovalevsky AY, Liu F, Leshchenko S, et al. (2006) Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114. Journal of Molecular Biology. 363: 161-73
Liu F, Kovalevsky AY, Louis JM, et al. (2006) Mechanism of drug resistance revealed by the crystal structure of the unliganded HIV-1 protease with F53L mutation. Journal of Molecular Biology. 358: 1191-9
Kovalevsky AY, Tie Y, Liu F, et al. (2006) Effectiveness of nonpeptide clinical inhibitor TMC-114 on HIV-1 protease with highly drug resistant mutations D30N, I50V, and L90M. Journal of Medicinal Chemistry. 49: 1379-87
Liu F, Boross PI, Wang YF, et al. (2005) Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S. Journal of Molecular Biology. 354: 789-800
Tie Y, Boross PI, Wang YF, et al. (2005) Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs. The Febs Journal. 272: 5265-77
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