Rene Maltais, Ph.D.

2001 Universite Laval (Canada) 
Pharmaceutical Chemistry
"Rene Maltais"
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Donald Poirier grad student 2001 Universite Laval (Canada)
 (Mise au point de nouvelles methodes de synthese combinatoire de derives steroidiens de type sulfamate, cetone et hydroxyle pour bloquer les effets proliferatifs des androgenes.)
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Boutin S, Maltais R, Roy J, et al. (2020) Synthesis of 17β-hydroxysteroid dehydrogenase type 10 steroidal inhibitors: Selectivity, metabolic stability and enhanced potency. European Journal of Medicinal Chemistry. 112909
Maltais R, Ngueta Djiemeny A, Roy J, et al. (2020) Design and synthesis of dansyl-labeled inhibitors of steroid sulfatase for optical imaging. Bioorganic & Medicinal Chemistry. 115368
Maltais R, Perreault M, Roy J, et al. (2019) Minor chemical modifications of the aminosteroid derivative RM-581 lead to major impact on its anticancer activity, metabolic stability and aqueous solubility. European Journal of Medicinal Chemistry. 188: 111990
Boutin S, Roy J, Maltais R, et al. (2019) Formation of 5α-dihydrotestosterone from 5α-androstane-3α,17β-diol in prostate cancer LAPC-4 cells - Identifying inhibitors of non-classical pathways producing the most potent androgen. Bioorganic & Medicinal Chemistry Letters. 126783
Cortés-Benítez F, Roy J, Perreault M, et al. (2019) A- and D-ring structural modifications of an androsterone derivative inhibiting 17β-hydroxysteroid dehydrogenase type 3: Chemical synthesis and structure-activity relationships. Journal of Medicinal Chemistry
Poirier D, Roy J, Maltais R, et al. (2019) Antisulfatase, osteogenic and anticancer activities of steroid sulfatase inhibitor EO-33 in mice. Journal of Medicinal Chemistry
Sancéau JY, Maltais R, Poirier D, et al. (2018) Total Synthesis of the Antidiabetic (Type 2) Lipid Mediator Protectin DX/PDX. The Journal of Organic Chemistry
Boutin S, Roy J, Maltais R, et al. (2018) Identification of steroidal derivatives inhibiting the transformations of allopregnanolone and estradiol by 17β-hydroxysteroid dehydrogenase type 10. Bioorganic & Medicinal Chemistry Letters
Lespérance M, Barbeau X, Roy J, et al. (2018) Chemical Synthesis of C3-oxiranyl/oxiranylmethyl-estrane derivatives targeted by molecular modeling and tested as potential inhibitors of 17β-hydroxysteroid dehydrogenase type 1. Steroids
Dutour R, Roy J, Cortés-Benítez F, et al. (2018) Targeting Cytochrome P450 (CYP) 1B1 Enzyme with Four Series of A-ring Substituted Estrane Derivatives: Design, Synthesis, Inhibitory Activity and Selectivity. Journal of Medicinal Chemistry
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