Rene Maltais, Ph.D.
Affiliations: | 2001 | Universite Laval (Canada) |
Area:
Pharmaceutical ChemistryGoogle:
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Parents
Sign in to add mentor| Donald Poirier | grad student | 2001 | Universite Laval (Canada) | |
| (Mise au point de nouvelles methodes de synthese combinatoire de derives steroidiens de type sulfamate, cetone et hydroxyle pour bloquer les effets proliferatifs des androgenes.) | ||||
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Publications
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| Boutin S, Maltais R, Roy J, et al. (2020) Synthesis of 17β-hydroxysteroid dehydrogenase type 10 steroidal inhibitors: Selectivity, metabolic stability and enhanced potency. European Journal of Medicinal Chemistry. 112909 |
| Maltais R, Ngueta Djiemeny A, Roy J, et al. (2020) Design and synthesis of dansyl-labeled inhibitors of steroid sulfatase for optical imaging. Bioorganic & Medicinal Chemistry. 115368 |
| Maltais R, Perreault M, Roy J, et al. (2019) Minor chemical modifications of the aminosteroid derivative RM-581 lead to major impact on its anticancer activity, metabolic stability and aqueous solubility. European Journal of Medicinal Chemistry. 188: 111990 |
| Boutin S, Roy J, Maltais R, et al. (2019) Formation of 5α-dihydrotestosterone from 5α-androstane-3α,17β-diol in prostate cancer LAPC-4 cells - Identifying inhibitors of non-classical pathways producing the most potent androgen. Bioorganic & Medicinal Chemistry Letters. 126783 |
| Cortés-Benítez F, Roy J, Perreault M, et al. (2019) A- and D-ring structural modifications of an androsterone derivative inhibiting 17β-hydroxysteroid dehydrogenase type 3: Chemical synthesis and structure-activity relationships. Journal of Medicinal Chemistry |
| Poirier D, Roy J, Maltais R, et al. (2019) Antisulfatase, osteogenic and anticancer activities of steroid sulfatase inhibitor EO-33 in mice. Journal of Medicinal Chemistry |
| Sancéau JY, Maltais R, Poirier D, et al. (2018) Total Synthesis of the Antidiabetic (Type 2) Lipid Mediator Protectin DX/PDX. The Journal of Organic Chemistry |
| Boutin S, Roy J, Maltais R, et al. (2018) Identification of steroidal derivatives inhibiting the transformations of allopregnanolone and estradiol by 17β-hydroxysteroid dehydrogenase type 10. Bioorganic & Medicinal Chemistry Letters |
| Lespérance M, Barbeau X, Roy J, et al. (2018) Chemical Synthesis of C3-oxiranyl/oxiranylmethyl-estrane derivatives targeted by molecular modeling and tested as potential inhibitors of 17β-hydroxysteroid dehydrogenase type 1. Steroids |
| Dutour R, Roy J, Cortés-Benítez F, et al. (2018) Targeting Cytochrome P450 (CYP) 1B1 Enzyme with Four Series of A-ring Substituted Estrane Derivatives: Design, Synthesis, Inhibitory Activity and Selectivity. Journal of Medicinal Chemistry |